How Rift Valley fever virus packages its genetic material
Investigation of RNA packaging in Rift Valley fever virus
Researchers are working to understand how Rift Valley fever virus packs its RNA to help prevent illness in people and animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11237090 on NIH RePORTER |
What this research studies
This project looks at how Rift Valley fever virus arranges its three RNA segments when making new virus particles. Scientists will examine infected cells and viral particles in the lab, using molecular tools to track RNA–protein interactions and the steps of viral assembly. They will also use animal models to test how disrupting packaging affects infection. Results aim to reveal vulnerabilities that could guide future vaccines, diagnostics, or treatments.
Who could benefit from this research
Good fit: If human sample collection or clinical studies are later added, ideal participants would be people in regions affected by Rift Valley fever or patients who have recovered and can donate samples.
Not a fit: People who are not at risk for Rift Valley fever or who have unrelated medical conditions are unlikely to receive direct benefit from this laboratory-focused project.
Why it matters
Potential benefit: If successful, this work could point to new vaccine or antiviral approaches that reduce severe disease, vision loss, and outbreaks from RVFV.
How similar studies have performed: Basic virology studies on other viruses have led to successful vaccines and antivirals, but the specific mechanisms of RNA packaging in RVFV remain less well understood and are a relatively novel target.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Makino, Shinji — University of Texas Med Br Galveston
- Study coordinator: Makino, Shinji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.