Comparing two solutions for endoscopic removal of early esophageal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a randomized, single-center study that aims to compare the efficacy of 0.4% hyaluronic acid solution and hydroxyethylamide solution during submucosal endoscopic resections of early esophageal neoplasms. Patients with superficial esophageal adenocarcinoma or squamous cell carcinoma will be enrolled and randomized based on the size of their lesions. The effectiveness of each solution will be evaluated based on the success of complete block resections and the number of additional injections required during the procedure. The study is conducted at the São Paulo Cancer Institute, focusing on improving outcomes for patients undergoing this type of endoscopic dissection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years of age
* Superficial esophageal adenocarcinoma or squamous cell carcinoma with indication of ESD after discussion in a multidisciplinary oncological board
* Signed informed consent form

Exclusion Criteria:

* Residual or recurrent esophageal lesions
* Ulcerated esophageal lesions
* Patients with severe cardiovascular, kidney or liver disease
* History of hypersensitivity to hyaluronic acid
* Pregnant or lactating women

Where it's running

• Instituto do Câncer do Estado de São Paulo
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Study coordinator: Fauze Maluf-Filho, PhD
• Email: fauze.maluf@terra.com.br
• Phone: +5511991919014

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.