Kelulut honey as an add-on treatment for juvenile open-angle glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, multicenter, phase 4 trial in Malaysia enrolling 60 patients with juvenile open-angle glaucoma who have achieved target intraocular pressure on standard therapy. Participants are assigned by center to a honey group that consumes 30 g of Kelulut honey daily for 90 days or to a control group that receives usual care without honey. Outcomes before and after the intervention include serum interleukin-6 (IL-6), retinal nerve fiber layer (RNFL) thickness, tear break-up time (TBUT) and Schirmer Test 1, with compliance tracked by daily diaries and return of used sachets. Blood samples are processed centrally and ocular imaging and dry eye tests are performed using standardized protocols, with allergic reactions or adverse events leading to discontinuation as needed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

JOAG patients age 15 years old and above until 40 years old at the time of diagnosis Compliant to conventional treatment achieved target intraocular pressure

Exclusion Criteria:

Patients with allergy to honey or honey-based products OCT signal less than 6/10 Concurrent retinal diseases and other optic neuropathies Systemic neurodegenerative disease Systemic comorbidities such as diabetes mellitus and autoimmune diseases Patients on other honey-based products for the last 3 months Patient who consumes honey-based products during the study duration of 3 months (monitoring via honey-diary, return of the used sachet during the follow up visits) Patients on anti-oxidants, traditional medications or herbal products for the last 3 months Topical usage of steroids, systemic steroids and non-steroidal anti-inflammatory drugs.

Sepsis Compliance less than 75%.

Where it's running

• Hospital Raja Perempuan Zainab II
  Kota Bharu, Kelantan, Malaysia Recruiting
• Hospital Sultan Ismail Petra
  Kuala Krai, Kelantan, Malaysia Recruiting
• Hospital Universiti Sains Malaysia
  Kubang Kerian, Kelantan, Malaysia Recruiting
• Hospital Sultanah Nur Zahirah
  Kuala Terengganu, Terengganu, Malaysia Recruiting

Study contacts

• Study coordinator: Thamarai Munirathinam, MD(Prague)
• Email: nitaraicz88@gmail.com
• Phone: +60177712935

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.