GLP-1 receptor agonists and dry eye in adults with type 2 diabetes and obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort follows adults with type 2 diabetes and obesity to see how GLP-1 receptor agonists relate to the presence and severity of dry eye disease. The study is prospective and does not specify an interventional protocol. Researchers will compare ocular surface outcomes before and after exposure to GLP-1 receptor agonists in eligible participants, while accounting for relevant ocular and systemic factors. Inclusion requires adults 18 or older who have not previously used GLP-1 receptor agonists, with informed consent. Exclusion criteria include pregnancy, significant hypoglycemia history, active intraocular inflammation, recent eye surgery, ketoacidosis history, and corneal transplant history. Lead sponsorship is from Attikon Hospital, with collaboration at a center in Athens, Greece.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years.
2. Patients who have not previously received GLP-1 receptor agonists (GLP-1 RAs).
3. Patients able to provide informed consent for participation in the study.

Exclusion Criteria:

1. Pregnant or breastfeeding patients.
2. History of multiple severe hypoglycemic episodes within the past two years.
3. Active intraocular inflammation in either eye, such as infectious conjunctivitis, keratitis, scleritis, endophthalmitis, or autoimmune uveitis.
4. Patients who have undergone cataract surgery or vitrectomy within the past 6 months.
5. History of ketoacidosis or metabolic acidosis.
6. History of corneal transplantation.

Where it's running

• 2nd Department of Internal Medicine, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Athens, GRC.
  Athens, Greece Recruiting

Study contacts

• Study coordinator: Vaia Lambadiari, MD, PhD
• Email: vlambadiari@gmail.com
• Phone: (0030)2105838000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.