Condition

Diffuse Midline Glioma, H3K27-altered clinical trials and research

• 2Clinical trials
• 14Countries

All recruiting trials (2)

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• New treatment for Diffuse Intrinsic Pontine Glioma

  This study is testing if a new drug called ONC201 can help kids with Diffuse Intrinsic Pontine Glioma live longer without their cancer getting worse, compared to an existing treatment called everolimus.

  Recruiting at 53 sites Phase 3 Gustave Roussy, Cancer Campus, Grand Paris · Brussels and 55 other locations · NCT05476939

Related topics

Quick answers

How many Diffuse Midline Glioma, H3K27-altered clinical trials are recruiting right now?

2, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in Belgium (1 trial), Denmark (1 trial), Finland (1 trial), France (1 trial), Greece (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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