Drug or treatment

Lorlatinib clinical trials

• 10Clinical trials
• 11Countries

Newest trials

All recruiting trials (10)

• NXP900 with Lorlatinib in ALK-positive NSCLC

  This study tests whether adding NXP900 to lorlatinib helps people with ALK-positive non-small cell lung cancer who have already received prior therapy.

  Recruiting Phase 1 Nuvectis Pharma, Inc. · Fairfax, Virginia · NCT07784959

• See if tirzepatide helps with lorlatinib-related weight gain in NSCLC patients

  This study tests whether tirzepatide can reduce rapid weight gain in adults with non-small cell lung cancer who are already taking lorlatinib.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT07782359

• Vortioxetine for cognitive problems in ALK/ROS1-positive NSCLC treated with lorlatinib

  This observational study tests whether vortioxetine can help with cognitive and neurological side effects in adults with ALK/ROS1-positive NSCLC who are taking lorlatinib.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá · NCT07633626

• Lorlatinib with local consolidation therapy for ALK-positive advanced non-small cell lung cancer

  This trial will test whether adding local consolidation treatments to lorlatinib helps people with ALK-positive advanced non-small cell lung cancer stay progression-free longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07415005

• Iruplinalkib for ALK-positive advanced lung adenocarcinoma after lorlatinib

  We will try iruplinalkib in adults with advanced ALK-positive lung adenocarcinoma who progressed on or couldn't tolerate lorlatinib to see how well it works and how safe it is in routine care.

  Recruiting Peking University Shenzhen Hospital · Shenzhen, Guangdong · NCT07374614

• Effectiveness and safety of Lorlatinib for untreated ALK-positive lung cancer patients in France

  This study is testing if Lorlatinib is safe and effective for adults in France who have not yet received treatment for ALK-positive lung cancer.

  Recruiting at 23 sites Pfizer · Toulouse, Haute-garonne and 31 other locations · NCT06487078

• Combining chemotherapy with Lorlatinib for ALK positive lung cancer

  This study is testing if combining chemotherapy with Lorlatinib can help people with ALK positive lung cancer who have seen their disease get worse while on Lorlatinib.

  Recruiting Phase 2 Centro di Riferimento Oncologico - Aviano · Aviano and 8 other locations · NCT06378892

• Lorlatinib for newly diagnosed high-grade glioma with ALK or ROS1 fusions

  This trial will test whether the oral medicine lorlatinib helps children and young adults (ages 1–21) with newly diagnosed high-grade gliomas that have ALK or ROS1 fusions, given alone, with chemotherapy, or after radiation.

  Recruiting at 2 sites Early Phase 1 Nationwide Children's Hospital · Aurora, Colorado and 17 other locations · NCT06333899

• First-line treatment with lorlatinib for advanced ALK+ lung cancer in China

  This study is testing if lorlatinib can be an effective first treatment for people in China with advanced ALK-positive lung cancer.

  Recruiting Phase 2 Guangdong Association of Clinical Trials · Guangzhou, Guangdong · NCT06092086

• Adding iobenguane I-131 or lorlatinib to intensive treatment for children and young adults with high-risk neuroblastoma

  This trial tests whether adding the radioactive drug iobenguane I-131 or the targeted drug lorlatinib to standard intensive therapy helps children and young adults with newly diagnosed high-risk neuroblastoma or nodular ganglioneuroblastoma stay free of disease longer.

  Recruiting at 153 sites Phase 3 Children's Oncology Group · Birmingham, Alabama and 163 other locations · NCT03126916

Quick answers

How many clinical trials of Lorlatinib are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (5 trials), China (2 trials), Canada (2 trials), Colombia (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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