Preventing colorectal cancer using Urolithin A in animal models
Official title: Colorectal Cancer (CRC) Prevention by Urolithin A in Rodent CRC models
Funded at Research Inst of Fox Chase Can Ctr · NIH-10885222 · Data updated 2026-11-12
This study is looking at whether a natural compound called Urolithin A, found in some fruits and nuts, can help prevent colorectal cancer by testing it in mice that have a similar condition to humans, with hopes that it could lead to new ways to protect people from this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 10, 2023 |
| Project end | July 9, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,038,958 |
| NIH project number | 75N91019D00022-0-759102300001-1 |
| Project ID | NIH-10885222 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adults at high risk for colorectal cancer, particularly those with a family history of the disease or genetic predispositions.
✕Less likely to help
Patients who have already been diagnosed with advanced colorectal cancer may not benefit from this research.
What this research studies
This research investigates the potential of Urolithin A, a compound derived from certain fruits and nuts, to prevent colorectal cancer (CRC) in rodent models. The study aims to understand how Urolithin A affects the development of precancerous lesions and the overall incidence of CRC. By using rodent models that mimic human CRC, researchers will explore the mechanisms through which Urolithin A may exert its protective effects. The findings could lead to new preventive strategies for CRC in humans.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or supplements that significantly reduce the risk of colorectal cancer.
How similar studies have gone: Previous research has shown promising results with similar compounds in cancer prevention, suggesting that this approach may be viable.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Clapper, Margie L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Clapper, Margie L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.