Preventing colorectal cancer using Urolithin A in animal models
Colorectal Cancer (CRC) Prevention by Urolithin A in Rodent CRC models
This study is looking at whether a natural compound called Urolithin A, found in some fruits and nuts, can help prevent colorectal cancer by testing it in mice that have a similar condition to humans, with hopes that it could lead to new ways to protect people from this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10885222 on NIH RePORTER |
What this research studies
This research investigates the potential of Urolithin A, a compound derived from certain fruits and nuts, to prevent colorectal cancer (CRC) in rodent models. The study aims to understand how Urolithin A affects the development of precancerous lesions and the overall incidence of CRC. By using rodent models that mimic human CRC, researchers will explore the mechanisms through which Urolithin A may exert its protective effects. The findings could lead to new preventive strategies for CRC in humans.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults at high risk for colorectal cancer, particularly those with a family history of the disease or genetic predispositions.
Not a fit: Patients who have already been diagnosed with advanced colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or supplements that significantly reduce the risk of colorectal cancer.
How similar studies have performed: Previous research has shown promising results with similar compounds in cancer prevention, suggesting that this approach may be viable.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Clapper, Margie L. — Research Inst of Fox Chase Can Ctr
- Study coordinator: Clapper, Margie L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.