Examining the large intestine with a camera capsule in patients with blood infections from gut bacteria
Colonic Capsule Endoscopy for Screening of Neoplasms in Patients With Anaerobic Bacteremia
Odense University Hospital · NCT06919068
This study is testing if a special camera pill can help find colorectal cancer and precancerous growths in adults who have had blood infections from gut bacteria.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Odense University Hospital (other) |
| Locations | 1 site (Odense) |
| Trial ID | NCT06919068 on ClinicalTrials.gov |
What this trial studies
This observational study aims to diagnose colorectal cancer and precancerous tumors in patients over 18 years old who are hospitalized with blood stream infections caused by anaerobic gut-associated bacteria. Participants will undergo colon capsule endoscopy 4-8 weeks after discharge to assess the prevalence of cancer and precancerous lesions in their large intestines and rectum. The study focuses on understanding the link between anaerobic bacteremia and colorectal malignancies.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a confirmed blood culture showing growth of specific anaerobic bacteria.
Not a fit: Patients with a prior diagnosis of colorectal cancer or significant gastrointestinal issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of colorectal cancer in patients with specific blood infections, potentially improving treatment outcomes.
How similar studies have performed: While this approach is observational and specific, similar studies have indicated a potential link between gut bacteria and colorectal cancer, suggesting a promising area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Older than 18 years * Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus. * Able to provide oral and written informed consent * Able to read and speak Danish Exclusion Criteria: * Prior colorectal cancer diagnosis * History of stenosis of the gastrointestinal tract * Previous treatment of inflammatory bowel disease * Previous major surgery of the gastrointesinal tract (e.g. gastric bypass) * Colostomy * Pacemaker/ICD * Pregnancy or breastfeeding * Allergies to the bowel preparation regimen * Severe kidney disease * Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer) * Tumor in the colon or rectum at diagnostic imaging * Transfer to other hospital outside the region
Where this trial is running
Odense
- Odense University Hospital — Odense, Denmark (RECRUITING)
Study contacts
- Study coordinator: Charlotte Nielsen Agergaard, MD
- Email: charlotte.agergaard@rsyd.dk
- Phone: 004565414797
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colorectal Cancer, Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection, Bacteriaemia, Anaerobic bacteria, Bacteria, anaerobic, Cancer, colorectal