Investigating Long COVID as a type of chronic fatigue syndrome

Long COVID as a putative subtype of chronic fatigue syndrome

NIH-funded research Massachusetts General Hospital · NIH-10903937

This study is looking into how Long COVID works and what might make some people more likely to experience it, especially since it has symptoms similar to chronic fatigue syndrome, to help find better treatments for those who are struggling with these ongoing issues.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMassachusetts General Hospital NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-10903937 on NIH RePORTER

What this research studies

This research aims to understand the biological mechanisms and risk factors associated with Long COVID, which shares symptoms with chronic fatigue syndrome (CFS). By analyzing data from multiple biobanks and a genetics working group, the study will explore genetic risk factors and immune responses in individuals affected by Long COVID. The goal is to determine whether Long COVID can be classified as a subtype of CFS, potentially leading to better treatment options for patients suffering from these debilitating symptoms.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals who have experienced Long COVID symptoms following a COVID-19 infection.

Not a fit: Patients who have not been infected with COVID-19 or do not exhibit symptoms of Long COVID may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Long COVID and chronic fatigue syndrome.

How similar studies have performed: Other research has indicated potential links between infectious triggers and chronic fatigue syndrome, suggesting that this approach may yield valuable insights.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.