Investigating T Cell Responses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Altered T Cell Responses in Myalgic Enchephalomeylitis/Chronic Fatigue Syndrome (ME/CFS)

['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11044125

This study is looking at how a type of immune cell called T cells behaves in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared to healthy individuals, to help uncover clues about the condition and find better ways to treat it.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded)
Locations1 site (WORCESTER, UNITED STATES)
Trial IDNIH-11044125 on ClinicalTrials.gov

What this research studies

This research focuses on understanding how T cells, a type of immune cell, respond in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The study examines the differences in T cell behavior between individuals with ME/CFS and healthy individuals, particularly looking at markers of T cell activation and exhaustion. By analyzing blood samples, researchers aim to identify specific patterns in T cell responses that may contribute to the symptoms of ME/CFS. This could lead to better understanding of the disease and potential new treatment strategies.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Not a fit: Patients with other chronic illnesses or those without a diagnosis of ME/CFS may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients with ME/CFS.

How similar studies have performed: Previous research has indicated alterations in immune responses in ME/CFS, suggesting that this approach may yield valuable insights.

Where this research is happening

WORCESTER, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.