A 3-day course for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

A 3-day Course for Adults With Chronic Fatigue Syndrome/Myalgic Encephalopathy (CFS/ME): a Randomized Controlled Trial

NA · Norwegian University of Science and Technology · NCT05236465

This study is testing if a 3-day program called the Lightning Process can help adults with Chronic Fatigue Syndrome feel better and improve their daily lives.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorNorwegian University of Science and Technology (other)
Locations1 site (Trondheim)
Trial IDNCT05236465 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effects of a 3-day course called the Lightning Process on adults diagnosed with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The course incorporates elements of stress theory and Positive Psychology to help participants regulate their thoughts, feelings, and behaviors, potentially improving their symptoms and quality of life. The study will assess both positive and negative outcomes, including disability and work participation, with a follow-up to evaluate long-term effects. Adverse events will be monitored and managed according to established protocols.

Who should consider this trial

Good fit: Ideal candidates are adults diagnosed with CFS/ME who are at least 50% out of school or work and are ready to engage in a change process.

Not a fit: Patients with underlying physical or mental disorders that explain their symptoms, those at risk of suicide, or those who are bedridden will not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the quality of life and functional capacity of patients with CFS/ME.

How similar studies have performed: While there is limited evidence on the effectiveness of the Lightning Process specifically, similar interventions focusing on psychological approaches have shown promise in managing CFS/ME symptoms.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* CFS/ME diagnosis based on the Canada Consensus Criteria.
* At least 50% out of school/work.
* Readiness to change (corresponding to the preparation phase in transtheoretical model)
* Has given informed consent.

Exclusion Criteria:

* Assessed by a General Practitioner (GP):
* Underlying physical illness or mental disorder that may explain the symptoms.
* Suicide risk/previous suicide attempts.
* Pregnancy.
* Bedridden and in need of continuous care.
* Insufficient Norwegian speaking or writing skills to participate in the 3-day course and fill out questionnaires.

Where this trial is running

Trondheim

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Health education, Chronic Fatigue Syndrome/Myalgic Encephalopathy, RCT, 3-day Course, Physical function, Fatigue

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.