Using topotecan and melphalan to treat retinoblastoma
Official title: Choice of Topotecan or Melphalan in Retinoblastoma Patients
Run by Sun Yat-sen University · NCT04799002 · Data updated 2026-11-12
This study is testing if giving the chemotherapy drugs topotecan and melphalan directly into the eye can effectively treat retinoblastoma while saving the eye from removal.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | March 11, 2021 |
| Main results expected | December 30, 2024 |
| Study ends | December 30, 2027 |
| Registry record updated | March 16, 2021 |
| Trial ID | NCT04799002 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with retinoblastoma who are receiving eyeball-sparing treatment.
✕Probably not a fit
Patients whose disease has progressed during follow-up may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness and potential complications of administering topotecan and melphalan through intraocular injection in patients diagnosed with retinoblastoma. It aims to provide a treatment option that spares the eyeball while addressing the cancer. The study is designed as a Phase 3 interventional trial, focusing on the outcomes of these chemotherapy agents in a specific patient population.
Why it matters
Potential benefit: If successful, this treatment could provide a less invasive option for retinoblastoma patients, preserving their eyesight while effectively managing the disease.
How similar studies have gone: While this approach is being evaluated in this specific context, similar studies using chemotherapy agents for retinoblastoma have shown promise, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosed as retinoblastoma * receiving eyeball-sparing treatment Exclusion Criteria: * disease progression during follow-up
Where it's running
-
Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Huashen Yang — Sun Yat-sen University
- Study coordinator: Huasheng Yang
- Email: yanghs64@126.com
- Phone: +00862087331539
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.