Investigating heart damage caused by cancer drugs using advanced human models
Official title: Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI System
Funded at University of North Texas · NIH-11192971 · Data updated 2026-11-12
This study is looking at how certain cancer drugs called tyrosine kinase inhibitors might affect your heart, using a new method that combines human heart tissue and advanced technology to help find any heart problems early on, making cancer treatments safer for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas NIH-funded |
| Lab location | 1 site (Denton, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $547,020 |
| NIH project number | 1R56HL174856-01 |
| Project ID | NIH-11192971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are being treated with tyrosine kinase inhibitors and may be at risk for cardiovascular complications.
✕Less likely to help
Patients who are not receiving tyrosine kinase inhibitors or those without any cardiovascular concerns may not benefit from this research.
What this research studies
This research focuses on understanding the heart-related side effects of tyrosine kinase inhibitors (TKIs), which are commonly used to treat various cancers. By developing a new human model using vascularized cardiac organoids, the study aims to accurately assess the cardiotoxic effects of these drugs. The approach combines advanced artificial intelligence with human-derived heart tissues to predict potential heart issues more effectively than traditional methods. This could lead to safer cancer treatments by identifying harmful side effects early in the drug development process.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer therapies by minimizing heart-related side effects associated with tyrosine kinase inhibitors.
How similar studies have gone: Previous research has shown promise in using human organoid models to study drug effects, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of North Texas
Denton, United States Active
Researchers
- Principal investigator: Yang, Huaxiao — University of North Texas
- Study coordinator: Yang, Huaxiao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.