Exercise and fitness program for breast cancer survivors to improve heart health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of structured exercise training and group-based yoga on heart and muscle health in breast cancer survivors aged 60 and older. It aims to address the decline in functional capacity and increased cardiovascular risk associated with chemotherapy treatments for breast cancer. Participants will be randomized to either an exercise training group or a stretching group to assess improvements in their physical function and overall health. The study seeks to fill a gap in current rehabilitation practices for this population by providing tailored exercise interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥60 years
* Previously diagnosed with early-stage (I-III) BC
* Completed (≥1 year post) primary cardiotoxic treatment (anthracycline-based chemotherapy or trastuzumab-based biological therapy).

Exclusion Criteria:

* Have a history of coronary artery disease, heart failure, persistent and permanent arrhythmia (e.g. currently in atrial fibrillation), stroke, or chronic obstructive pulmonary disease
* Develop signs or symptoms of myocardial ischemia (≥1mm horizontal or down-sloping ST segment depression on electrocardiogram) during the cardiopulmonary (VO2peak) test
* Have any research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing
* Currently performing structured exercise training (defined as ≥30 mins/day of moderate-to-vigorous aerobic and/or resistance exercise training on ≥4 days/week)
* Are unwilling to be randomized to either ExT or STRETCH

Where it's running

• University of Alberta
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Study coordinator: Nathan Weeldreyer, PhD
• Email: ageheart@ualberta.ca
• Phone: 616.566.6756

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.