Cardiac rehabilitation for young cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of a Cardio-Oncology Rehabilitation (CORE) program for pediatric, adolescent, and young adult cancer survivors who are at increased risk of cardiovascular issues due to their cancer treatments. Participants will engage in a six-month structured exercise program that includes both home and onsite training, aimed at improving their cardiovascular health and overall fitness. The study will assess changes in physical fitness, cardiac function, and psychosocial well-being among participants. By focusing on non-pharmacological interventions, this trial seeks to address the unique health challenges faced by this underserved population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Be a PAYA-CS, defined as ≤39 years of age at the time of cancer diagnosis;
2. Be 18-45 years of age at the time of enrolment;
3. Received cancer treatment(s) with known cardiovascular risks (e.g., anthracyclines, trastuzumab, radiotherapy, platinum-based agents, vascular endothelial growth factor inhibitors, tyrosine kinase inhibitors);
4. Be cancer-free at the time of enrollment;
5. Stage B Heart Failure (SBHF)

   * In patients with availability of pre-treatment imaging:

     * ≥10% decrease in LVEF at post-treatment compared to pre-treatment
     * ≥15% decrease in GLS at post-treatment compared to pre-treatment
   * No pre-treatment imaging:

     * LVEF ≤53% in women/51% in men
     * GLS \>-18%
     * Left ventricular hypertrophy (LV mass/body surface area: \>95 g/m2 for women or \>115 g/m2 for men)
     * Concentric remodelling (\>0.42 relative wall thickness)
     * Diastolic dysfunction (≥ grade 1)
     * BNP ≥35pg/ml or NT-proBNP ≥125pg/ml

Exclusion Criteria:

1. Have an absolute or unresolved relative contraindication to exercise according to the American College of Sports Medicine guidelines;
2. Have an untreated physical or mental health concern that precludes safe and effective exercise participation;
3. Have established CVD (excluding mildly reduced LVEF as described above);
4. Be pregnant at time of recruitment;
5. Be currently engaging in frequent high-intensity exercise (\>1 high-intensity exercise session per week);
6. Have substantial barriers to participating, including (1) living too far from study centre or (2) being unable or willing to comply with the study protocol.

Where it's running

• University Health Network
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Paaladinesh Thavendiranathan, MD
• Email: dinesh.thavendiranathan@uhn.ca
• Phone: 416-340-5326

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.