Effects of exercise training in lymphoma survivors
The LYMfit Study: Exercise Training to Prevent Cardiovascular Disease in Lymphoma Survivors
This study is testing whether adding aerobic and resistance exercise to usual care can improve fitness and health for people who have survived lymphoma.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 280 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Norwegian School of Sport Sciences Academic / other |
| Drugs / interventions | radiation |
| Locations | 2 sites (Oslo and 1 other locations) |
| Trial ID | NCT06270667 on ClinicalTrials.gov |
What this trial studies
This study compares the effects of aerobic exercise with or without resistance exercise to usual care in individuals treated with anthracyclines for lymphoma. It includes a randomized controlled trial with lymphoma survivors and a reference group of age- and sex-matched individuals without a history of cancer. The primary endpoint is the change in cardiorespiratory fitness, assessed as VO2peak, while secondary endpoints include cardiovascular risk factors and patient-reported outcomes. Participants will be recruited through invitation only.
Who should consider this trial
Good fit: Ideal candidates are lymphoma survivors who completed treatment 2-5 years ago and are not currently engaging in significant aerobic exercise.
Not a fit: Patients with a history of cancer relapse or other invasive cancers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve cardiovascular health and fitness in lymphoma survivors.
How similar studies have performed: Other studies have shown positive outcomes with exercise interventions in cancer survivors, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria Lymphoma participants: * Listed in relevant registers * Confirmed lymphoma diagnosis (i.e., Hodgkin lymphoma and aggressive non-Hodgkin lymphoma) * Completed treatment in the past two to five years without relapse or second cancer * Previous anthracycline treatment with or without mediastinal radiation * No severe cancer-related fatigue (per self-report) Inclusion Criteria Lymphoma participants and non-cancer reference group: * Currently not performing \>75 minutes/week of aerobic exercise * Willing and able to adhere to all study procedures. Exclusion Criteria Lymphoma participants: * Relapse since diagnosis * A history, or current presence, of another diagnosis of invasive cancer of any kind Exclusion Criteria Lymphoma participants and non-cancer reference group: * Presence of any uncontrolled- or recent cardiovascular disease * Has undergone heart surgery * Uses a pacemaker * Pregnancy * Unable to read and understand Swedish (applicable for the Swedish site only) * Unable to read and understand Norwegian (applicable for the Norwegian site) * Any physical or mental health condition restricting adherence to study protocol
Where this trial is running
Oslo and 1 other locations
- Norweigan School of Sport Sciences — Oslo, Norway (Not_yet_recruiting)
- Helena Igelström — Uppsala, Sweden (Recruiting)
Study contacts
- Principal investigator: Tormod S. Nilsen, PhD — Norwegian School of Sport Sciences
- Study coordinator: Tormod S. Nilsen, PhD
- Email: tormodsn@nih.no
- Phone: 95069857
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.