Clinical trial Recruiting at 1 site Interventional Ages 65 and up

Preventing heart issues in elderly cancer patients

Official title: Cardiotoxicity in the Elderly. Comparative Clinical Trial Between Primary Versus Secondary Cardiovascular Prevention Strategies

Run by Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · NCT03711110 · Data updated 2026-11-12

This study is testing whether close heart monitoring and teamwork among doctors can help older cancer patients avoid heart problems and live longer compared to standard care.

Quick facts

Study typeInterventional
Ages65 Years and up
SexAll
Enrollment514 (estimated)
SponsorFundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Academic / other
Locations14 sites (Santiago de Compostela, A Coruña and 13 other locations)
StatusRecruiting
StartedAugust 2, 2019
Main results expectedAugust 2, 2024
Study endsNovember 30, 2025
Registry record updatedMarch 21, 2025
Trial IDNCT03711110 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are elderly patients over 65 years old with specific types of cancer and an expected survival of more than one year.

Probably not a fit

Patients currently enrolled in other clinical trials that interfere with the CARTIER follow-up protocol may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CARTIER study is a randomized, multicenter clinical trial aimed at comparing two strategies for preventing cardiotoxicity in elderly cancer patients undergoing anti-tumoral treatment. It evaluates the effectiveness of intensive cardiovascular monitoring and multidisciplinary management against the current standard practice, which lacks routine monitoring. The primary goal is to determine if the proactive approach can reduce all-cause mortality compared to conventional care. Secondary objectives include assessing the impact on cardiovascular and oncological mortality rates.

Why it matters

Potential benefit: If successful, this study could significantly reduce mortality rates in elderly cancer patients by improving cardiotoxicity management.

How similar studies have gone: Other studies have shown promise in similar approaches to managing cardiotoxicity in cancer patients, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* \> 65 years old
* Expected survival \>1 year
* Colon cancer, breast cancer, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia, myeloma
* Signature on the informed consent

Exclusion Criteria:

* Patients included in clinical trials will be excluded if they interfere with the CARTIER follow-up protocol. If they do not interfere they can be included
* Patients who had received previous potentially cardiotoxic anticancer treatment

Where it's running

  • Complejo Asistencial Universitario de Salamanca
    Salamanca, Spain
    Recruiting
  • Hospital Clínico Universitario de Santiago de Compostela
    Santiago de Compostela, A Coruña, Spain
    Not yet recruiting
  • Hospital de Galdakao-Usansolo
    Galdakao, Vizcaya, Spain
    Not yet recruiting
  • Hospital Universitario Vall d´Hebron
    Barcelona, Spain
    Not yet recruiting
  • Hospital Universitario Reina Sofía
    Córdoba, Spain
    Not yet recruiting
  • Hospital Universitario de La Princesa
    Madrid, Spain
    Not yet recruiting
Show 8 more locations
  • Hospital G. Universitario Gregorio Marañón
    Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Ramón y Cajal
    Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Fundación Jiménez Díaz
    Madrid, Spain
    Not yet recruiting
  • Hospital Universitario 12 de Octubre
    Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Puerta de Hierro
    Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Virgen de la Victoria
    Málaga, Spain
    Not yet recruiting
  • Hospital Universitario Virgen del Rocío
    Seville, Spain
    Not yet recruiting
  • Hospital Universitario Río Hortega
    Valladolid, Spain
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.