Preventing heart issues in elderly cancer patients
Official title: Cardiotoxicity in the Elderly. Comparative Clinical Trial Between Primary Versus Secondary Cardiovascular Prevention Strategies
Run by Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · NCT03711110 · Data updated 2026-11-12
This study is testing whether close heart monitoring and teamwork among doctors can help older cancer patients avoid heart problems and live longer compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 514 (estimated) |
| Sponsor | Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Academic / other |
| Locations | 14 sites (Santiago de Compostela, A Coruña and 13 other locations) |
| Status | Recruiting |
| Started | August 2, 2019 |
| Main results expected | August 2, 2024 |
| Study ends | November 30, 2025 |
| Registry record updated | March 21, 2025 |
| Trial ID | NCT03711110 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are elderly patients over 65 years old with specific types of cancer and an expected survival of more than one year.
✕Probably not a fit
Patients currently enrolled in other clinical trials that interfere with the CARTIER follow-up protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The CARTIER study is a randomized, multicenter clinical trial aimed at comparing two strategies for preventing cardiotoxicity in elderly cancer patients undergoing anti-tumoral treatment. It evaluates the effectiveness of intensive cardiovascular monitoring and multidisciplinary management against the current standard practice, which lacks routine monitoring. The primary goal is to determine if the proactive approach can reduce all-cause mortality compared to conventional care. Secondary objectives include assessing the impact on cardiovascular and oncological mortality rates.
Why it matters
Potential benefit: If successful, this study could significantly reduce mortality rates in elderly cancer patients by improving cardiotoxicity management.
How similar studies have gone: Other studies have shown promise in similar approaches to managing cardiotoxicity in cancer patients, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \> 65 years old * Expected survival \>1 year * Colon cancer, breast cancer, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia, myeloma * Signature on the informed consent Exclusion Criteria: * Patients included in clinical trials will be excluded if they interfere with the CARTIER follow-up protocol. If they do not interfere they can be included * Patients who had received previous potentially cardiotoxic anticancer treatment
Where it's running
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Complejo Asistencial Universitario de Salamanca
Salamanca, Spain Recruiting -
Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, A Coruña, Spain Not yet recruiting -
Hospital de Galdakao-Usansolo
Galdakao, Vizcaya, Spain Not yet recruiting -
Hospital Universitario Vall d´Hebron
Barcelona, Spain Not yet recruiting -
Hospital Universitario Reina Sofía
Córdoba, Spain Not yet recruiting -
Hospital Universitario de La Princesa
Madrid, Spain Not yet recruiting
Show 8 more locations
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Hospital G. Universitario Gregorio Marañón
Madrid, Spain Not yet recruiting -
Hospital Universitario Ramón y Cajal
Madrid, Spain Not yet recruiting -
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain Not yet recruiting -
Hospital Universitario 12 de Octubre
Madrid, Spain Not yet recruiting -
Hospital Universitario Puerta de Hierro
Madrid, Spain Not yet recruiting -
Hospital Universitario Virgen de la Victoria
Málaga, Spain Not yet recruiting -
Hospital Universitario Virgen del Rocío
Seville, Spain Not yet recruiting -
Hospital Universitario Río Hortega
Valladolid, Spain Not yet recruiting
Study contacts
- Study coordinator: Pedro L Sánchez, Ph. D.
- Email: plsanchez@saludcastillayleon.es
- Phone: 923 291100
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.