3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, two-center observational study enrolls adults with breast cancer, lymphoma, or sarcoma who are planned to receive anthracyclines and/or HER2-targeted therapy. Participants undergo standardized echocardiography including both 2D and 3D strain analyses, with 3D left and right ventricular measurements and 3D LVEF, plus cardiac biomarkers at multiple time points. The goal is to determine if 3D speckle-tracking strain identifies subclinical cardiotoxicity earlier or more accurately than conventional 2D measures. Data will come from Skåne University Hospital in Lund and Malmö, Sweden. The study will help clarify the potential added value of 3D strain in monitoring CTRCD during cancer treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Diagnosis of breast cancer, lymphoma or sarcoma
* Scheduled for treatment with anthracyclines and/or HER2-targeted therapy
* Referred for baseline echocardiography before start of cancer therapy at Skåne University Hospital, Lund or Malmö
* Written informed consent

Exclusion Criteria:

* Pregnancy
* Inability to provide informed consent
* Insufficient image quality for 3D speckle-tracking analysis at baseline echocardiography

Where it's running

• Skåne University Hospital Lund and Malmö
  Lund, Skåne County, Sweden Recruiting

Study contacts

• Principal investigator: Ashkan Labaf, MD, PhD — Skåne University Hospital and Lund University, Lund, Sweden
• Study coordinator: Ashkan Labaf, MD, PhD
• Email: ashkan.labaf@med.lu.se
• Phone: +4646-171000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.