Investigating heart damage caused by cancer treatments using lab-grown heart cells.
Official title: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes
Funded at Vala Sciences, INC. · NIH-11142332 · Data updated 2026-11-12
This study is looking at how some cancer treatments might harm the heart, using special lab-grown heart cells to see how chemotherapy affects heart function, which could help make cancer treatments safer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vala Sciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $174,007 |
| NIH project number | 3R42HL158510-03S1 |
| Project ID | NIH-11142332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing or have undergone chemotherapy and are at risk of developing heart problems.
✕Less likely to help
Patients who have not received cancer treatment or those without any history of cardiac issues may not benefit from this research.
What this research studies
This research focuses on understanding how certain cancer treatments can lead to heart damage, known as cardiotoxicity. By using lab-grown heart cells derived from induced pluripotent stem cells (iPSCs), researchers aim to study the effects of chemotherapy on heart function without relying on animal models. The approach involves measuring electrical signals and calcium levels in these cells to identify potential risks of arrhythmias and other cardiac issues. This innovative method could provide insights into safer cancer treatment options for patients.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer therapies that minimize heart-related side effects for patients.
How similar studies have gone: Previous research has shown promise in using iPSC-derived cardiomyocytes to study drug effects, indicating that this approach could yield valuable insights.
Where this research is happening
-
Vala Sciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Price, Jeffrey H. — Vala Sciences, INC.
- Study coordinator: Price, Jeffrey H.
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Investigating heart damage caused by cancer treatments using lab-grown heart cells.
This study is looking at how some cancer treatments might hurt the heart, and it's for anyone interested in making cancer therapies safer by using lab-grown heart cells to see how these drugs affect heart function.
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Investigating heart damage caused by cancer treatments using lab-grown heart cells.
This study is looking at how some cancer treatments might harm the heart, using special lab-grown heart cells to see how chemotherapy affects heart function, which could help doctors better understand and predict heart problems in cancer survivors.
-
Investigating heart damage caused by cancer treatments using lab-grown heart cells.
This study is looking at how some cancer treatments might harm the heart, using special heart cells grown in the lab to see how chemotherapy affects them, which could help make cancer treatments safer for patients like you.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.