Cognitive-sparing radiosurgery for brain metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of advanced imaging techniques to guide stereotactic radiosurgery (SRS) in patients with brain metastases, aiming to minimize cognitive decline post-treatment. The study employs diffusion tensor imaging (DTI) and volumetric imaging to identify and protect critical brain regions during SRS. By evaluating cognitive performance and measuring changes in brain structure over time, the trial seeks to enhance patient outcomes and preserve neurocognitive function. Participants will be monitored for cognitive changes and imaging biomarkers following treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients 18 years or older
2. Eligible for intracranial SRS: Limited brain metastases targets geometrically feasible for SRS (intact or resected tumor bed), meningioma, or cerebral AVM
3. Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, \<50% in bed during the day)
4. Ability to answer questions and follow commands via neurocognitive testing
5. Estimated life expectancy greater than 6 months
6. Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion if brain metastasis
7. Willingness/Ability to undergo brain MRI scans
8. Able to give informed consent

Exclusion Criteria:

1. Pregnant or nursing women
2. Women of childbearing potential unwilling to use adequate contraception
3. Inability to complete a magnetic resonance imaging scan with contrast
4. Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
5. Planned chemotherapy during SRS (on the day of SRS)
6. Previous whole brain radiation therapy
7. Leptomeningeal metastases (ineligible for SRS)
8. Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS)

Where it's running

• Moores Cancer Center
  San Diego, California, United States Recruiting

Study contacts

• Principal investigator: Jona Hattangadi-Gluth, MD — University of California, San Diego
• Study coordinator: Sheila Medina
• Email: s4medina@health.ucsd.edu
• Phone: 858-822-6575

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.