Identifying biomarkers for HIV-related lymphoma in Malawi and South Africa
Project 3: Tumor-associated biomarkers for HIV-associated Diffuse Large B-cell Lymphoma in Malawi and South Africa
This study is looking at how certain markers in tumors can help doctors better diagnose and treat HIV-related lymphoma in patients in Malawi and South Africa, aiming to improve care for those facing this challenge.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10891547 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain tumor-associated biomarkers can improve the diagnosis and treatment of HIV-associated Diffuse Large B-cell Lymphoma (DLBCL) in Malawi and South Africa. By studying a cohort of patients, the research aims to identify biological differences in DLBCL that occur in HIV-infected individuals compared to those who are immunocompetent. The approach includes analyzing the tumor microenvironment and using regionally generated biomarkers to enhance patient outcomes. This work seeks to address the unique challenges faced by patients in sub-Saharan Africa, where the incidence of lymphoma is rising due to high rates of HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HIV-associated Diffuse Large B-cell Lymphoma in Malawi or South Africa.
Not a fit: Patients who do not have HIV or are not diagnosed with Diffuse Large B-cell Lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients with HIV-associated lymphoma, ultimately enhancing survival rates.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for various cancers, suggesting that this approach could yield valuable insights for HIV-associated lymphoma as well.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Fedoriw, Yuri — Univ of North Carolina Chapel Hill
- Study coordinator: Fedoriw, Yuri
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.