Understanding how specific mutations in EZH2 affect B-cell lymphoma
Official title: Dissecting mechanistic differences between EZH2 gain-of-function events in B-cell lymphoma
Funded at Washington University · NIH-11067470 · Data updated 2026-11-12
This study is looking at how two different changes in the EZH2 gene affect B-cell lymphoma, using special mice to see how these changes influence the growth and survival of B-cells, which could help us understand how this type of cancer develops.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $36,046 |
| NIH project number | 1F31CA298288-01 |
| Project ID | NIH-11067470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with B-cell lymphoma, particularly those with mutations in the EZH2 gene.
✕Less likely to help
Patients with other types of lymphoma or those without EZH2 mutations may not benefit from this research.
What this research studies
This research investigates the differences between two specific mutations in the EZH2 gene that are linked to B-cell lymphoma. By using genetically engineered mouse models, the study will analyze how these mutations influence B-cell behavior, including their growth and survival. The researchers will employ advanced techniques such as flow cytometry and RNA sequencing to explore the underlying mechanisms of these mutations and their impact on lymphoma development. This work aims to clarify whether these mutations act at different stages of cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to more targeted therapies for patients with B-cell lymphoma based on their specific genetic mutations.
How similar studies have gone: Previous research has shown promising results in understanding genetic mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Smith, Sofia R — Washington University
- Study coordinator: Smith, Sofia R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.