Understanding how specific mutations in EZH2 affect B-cell lymphoma
Dissecting mechanistic differences between EZH2 gain-of-function events in B-cell lymphoma
This study is looking at how two different changes in the EZH2 gene affect B-cell lymphoma, using special mice to see how these changes influence the growth and survival of B-cells, which could help us understand how this type of cancer develops.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11067470 on NIH RePORTER |
What this research studies
This research investigates the differences between two specific mutations in the EZH2 gene that are linked to B-cell lymphoma. By using genetically engineered mouse models, the study will analyze how these mutations influence B-cell behavior, including their growth and survival. The researchers will employ advanced techniques such as flow cytometry and RNA sequencing to explore the underlying mechanisms of these mutations and their impact on lymphoma development. This work aims to clarify whether these mutations act at different stages of cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with B-cell lymphoma, particularly those with mutations in the EZH2 gene.
Not a fit: Patients with other types of lymphoma or those without EZH2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more targeted therapies for patients with B-cell lymphoma based on their specific genetic mutations.
How similar studies have performed: Previous research has shown promising results in understanding genetic mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Smith, Sofia R — Washington University
- Study coordinator: Smith, Sofia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.