Understanding how the surrounding tissue affects B-cell lymphoma growth and immune response
Official title: Role of the stromal microenvironment in B-cell lymphoma progression and immune escape
Funded at Weill Medical Coll of Cornell Univ · NIH-10746427 · Data updated 2026-11-12
This study is looking at how certain cells and structures around lymphoma tumors help the cancer grow and avoid the immune system, with the goal of finding new ways to treat patients with diffuse large B-cell lymphoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $497,796 |
| NIH project number | 5R01CA242069-05 |
| Project ID | NIH-10746427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with diffuse large B-cell lymphoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of lymphoma or those who do not have a diagnosis of diffuse large B-cell lymphoma may not benefit from this research.
What this research studies
This research investigates the role of the stromal microenvironment in the progression of diffuse large B-cell lymphoma (DLBCL), an aggressive type of cancer. The study focuses on how cancer-associated fibroblasts and extracellular matrix components contribute to the survival and immune evasion of lymphoma cells. By exploring the mechanisms of how these stromal elements are reprogrammed by cancer cells, the research aims to identify potential therapeutic targets that could improve treatment outcomes for patients with DLBCL.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the effectiveness of treatments for patients with diffuse large B-cell lymphoma.
How similar studies have gone: Other research has shown promise in targeting the tumor microenvironment in various cancers, suggesting that this approach may yield beneficial results for DLBCL as well.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Cerchietti, Leandro C — Weill Medical Coll of Cornell Univ
- Study coordinator: Cerchietti, Leandro C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.