Identifying important cell markers in B cell lymphoma
Spatially resolved, single cell biomarkers of B cell lymphoma
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10895500
This study is looking at a common type of lymphoma called Diffuse Large B-Cell Lymphoma (DLBCL) to find new ways to predict how well patients will respond to treatment by examining both cancer and non-cancer cells in the tumor, which could help create more personalized and effective therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10895500 on ClinicalTrials.gov |
What this research studies
This research focuses on Diffuse Large B-Cell Lymphoma (DLBCL), the most common type of Non-Hodgkin Lymphoma. It aims to develop new biomarkers that include both cancerous and non-cancerous cells in the tumor environment, which can influence tumor growth and treatment response. By analyzing over 2000 cases using advanced imaging techniques, the study seeks to identify specific protein markers that can predict patient outcomes and understand how certain elements in the tumor environment affect resistance to therapies. This could lead to more effective treatments tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with aggressive B cell lymphomas, particularly those with Diffuse Large B-Cell Lymphoma.
Not a fit: Patients with non-aggressive forms of lymphoma or those without a confirmed diagnosis of B cell lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with B cell lymphoma, enhancing their chances of recovery.
How similar studies have performed: Previous research has shown promise in using similar approaches to identify biomarkers in other cancers, suggesting potential for success in this area as well.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERCHANT, AKIL — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: MERCHANT, AKIL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.