Identifying important cell markers in B cell lymphoma
Official title: Spatially resolved, single cell biomarkers of B cell lymphoma
Funded at Cedars-Sinai Medical Center · NIH-10895500 · Data updated 2026-11-12
This study is looking at a common type of lymphoma called Diffuse Large B-Cell Lymphoma (DLBCL) to find new ways to predict how well patients will respond to treatment by examining both cancer and non-cancer cells in the tumor, which could help create more personalized and effective therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $768,055 |
| NIH project number | 5R01CA266544-03 |
| Project ID | NIH-10895500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with aggressive B cell lymphomas, particularly those with Diffuse Large B-Cell Lymphoma.
✕Less likely to help
Patients with non-aggressive forms of lymphoma or those without a confirmed diagnosis of B cell lymphoma may not benefit from this research.
What this research studies
This research focuses on Diffuse Large B-Cell Lymphoma (DLBCL), the most common type of Non-Hodgkin Lymphoma. It aims to develop new biomarkers that include both cancerous and non-cancerous cells in the tumor environment, which can influence tumor growth and treatment response. By analyzing over 2000 cases using advanced imaging techniques, the study seeks to identify specific protein markers that can predict patient outcomes and understand how certain elements in the tumor environment affect resistance to therapies. This could lead to more effective treatments tailored to individual patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with B cell lymphoma, enhancing their chances of recovery.
How similar studies have gone: Previous research has shown promise in using similar approaches to identify biomarkers in other cancers, suggesting potential for success in this area as well.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Merchant, Akil — Cedars-Sinai Medical Center
- Study coordinator: Merchant, Akil
Related research
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Immune Evasion by HLA-E in Diffuse Large B-Cell Lymphoma
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Cardioprotective treatment choices for DLBCL patients at risk of heart damage
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Translating Genomics to Practice to Overcome Disparities in DLBCL
A patient-focused project aims to understand why diffuse large B-cell lymphoma outcomes differ among people and how genomic information can guide better care for diverse groups.
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Spatially resolved single-cell biomarkers to guide B cell lymphoma therapy
Aims to map tiny details in the tumor and immune cells of diffuse large B-cell lymphoma to help predict outcomes and guide treatments.
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From pathogenesis to new targets for treating diffuse large B-cell lymphoma
A patient-focused look at how this research aims to uncover new genetic clues to guide targeted therapies for diffuse large B-cell lymphoma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.