Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized study, 60 adults undergoing nonsurgical retreatment for asymptomatic apical periodontitis are assigned to one of four groups: no extra agitation, standard syringe agitation, passive ultrasonic irrigation, or laser-assisted irrigation during antimicrobial photodynamic therapy with methylene blue. Samples are collected at three treatment stages to analyze microbiology, inflammation, and healing, with a subset undergoing metagenomic sequencing. All participants receive the same photosensitizer and light activation using the FotoSan device, and are followed for 12 months. The goal is to determine if more effective agitation methods enhance clinical outcomes and microbiological control compared with basic aPDT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-65 years.
* No history of systemic disease.
* Non-smokers.
* Not pregnant or breastfeeding.
* Provision of written informed consent.
* Willingness to attend follow-up appointments for 12 months

Exclusion Criteria:

* Teeth with internal or external root resorption.
* Teeth with moderate or severe root canal curvature.
* Teeth with open apices.
* Teeth with periodontal probing depths ≥4 mm.
* Teeth in which adequate rubber dam isolation cannot be achieved.
* Teeth considered non-restorable.
* Teeth requiring post retention.
* Teeth with radiographically determined periapical lesions larger than 5.
* Systemic antibiotic or anti-inflammatory medication use within the preceding month.

Where it's running

• Karadeniz Technical University Faculty of Dentistry
  Trabzon, Ortahisar, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Nihan Çelik Uzun, Assistant Professor — Karadeniz Technical University Faculty of Dentistry
• Study coordinator: Nihan Çelik Uzun, Assistant Professor
• Email: nihancelik@ktu.edu.tr
• Phone: +90 5557256407

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Cryotherapy after retreatment of a tooth: does cooling the canal reduce pain and inflammation?

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• i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.