Two irrigation methods and activation techniques during a single-visit retreatment: does pain differ after root canal retreatment?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized trial compares two root canal irrigation protocols and activation techniques used during retreatment of mature, single-rooted teeth with asymptomatic apical periodontitis. Eligible participants are adults 18–60 who are healthy, have had a prior root canal treatment at least four years ago, and meet specific radiographic and clinical criteria. Participants will undergo retreatment with one of the irrigation strategies, and postoperative pain will be assessed to determine if one method provides less pain than the other. The study is conducted at Erciyes University, led by TC Erciyes University, with no stated collaborators. Safety and eligibility are reviewed to exclude those with recent analgesic use, certain dental complications, or pregnancy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),

  * Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,
  * Teeth with previous root canal obturation 2-4 mm short of the apex,
  * Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,
  * Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
  * Teeth suitable for rubber dam isolation.

Exclusion Criteria:

* o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,

  * Teeth exhibiting periodontal attachment loss,
  * Presence of vertical root fractures, external root resorption, or perforations,
  * Teeth with retained broken instruments,
  * Non-restorable teeth,
  * Patients in the pregnancy and breastfeeding period.

Where it's running

• Erciyes University
  Kayseri, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: İpek E Eraslan Akyüz
• Email: ipekemamak@hotmail.com
• Phone: +905385591409

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

  This trial tests whether different methods of agitating methylene blue during antimicrobial photodynamic therapy can improve healing and reduce infection in teeth that prior root canals had treated for asymptomatic apical periodontitis.

  Recruiting Karadeniz Technical University · Trabzon, Ortahisar · NCT07921277

• Conventional and nano-metronidazole irrigation with or without ultrasonic activation for necrotic single-rooted teeth with apical periodontitis

  This study tests whether conventional metronidazole or a nano-formulated version, used as root canal irrigants with or without ultrasonic activation, can reduce post-operative pain and endotoxin levels in necrotic single-rooted teeth with apical periodontitis.

  Recruiting October 6 University · Giza, Giza Governorate · NCT07897591

• Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

  This study tests whether laser-activated irrigation or sonic activation helps reduce post-operative pain and improve healing after re-treating a tooth with persistent apical inflammation, compared to conventional needle irrigation.

  Recruiting at 2 sites University Ghent · Antwerp and 1 other locations · NCT07883486

• Different endodontic motor motions during root canals and their effect on pain

  This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Antalya · NCT07714733

• i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

  This trial will see if adding injectable platelet-rich fibrin (i-PRF) to regenerative treatment helps adults 18–50 with failed root canals and periapical lesions heal better than standard non-surgical retreatment.

  Recruiting Marmara University · Istanbul · NCT07448571

• How French dentists treat infected or non-vital baby (primary) teeth

  See how dentists in France treat children’s non-vital or infected primary teeth and what leads them to choose extraction, pulpectomy, or other options.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07297836

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.