Revitalizing traumatized immature permanent teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effectiveness of revitalization procedures on immature permanent teeth with and without (a)symptomatic apical periodontitis. It aims to compare outcomes such as root development, periapical bone healing, pulp sensitivity, and tooth survival over a period of up to three years. The study will involve a multicenter approach with blinded assessments for radiographic analysis and statistical evaluation, although operators and patients cannot be blinded due to practical constraints.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of Informed Consent
* Female and male patients
* Age range: 6-18 years
* "Healthy": ASA I and II
* Permanent immature tooth (Cvek stage of root maturation ≤ 2) requiring revitalization
* Etiological factor: (a)symptomatic apical periodontitis post dental trauma or irreversible pulpitis post dental trauma

Exclusion Criteria:

* Unlikely to be able to comply with the study procedures, as judged by the investigator
* Patients older than 18 years and younger than 6
* Deciduous teeth
* Cvek root maturation stage \> 2: permanent immature tooth that can be treated by conventional root canal treatment or apexification
* Known or suspected current malignancy
* History of chemotherapy within 5 years prior to study
* History of radiation in the head and neck region
* History of other metabolic bone diseases
* Bleeding disorders
* Involvement in the planning and conduct of the study

Where it's running

• Ghent University
  Ghent, Belgium Recruiting

Study contacts

• Study coordinator: Nastaran Meschi, MSc, PhD
• Email: nastaran.meschi@ugent.be
• Phone: +32476313889

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.