Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares three irrigation approaches during orthograde re-treatment of previously treated teeth with asymptomatic apical periodontitis: laser-activated irrigation, sonic-activated irrigation, and conventional needle irrigation. Eligible adults have mature permanent teeth with pulpal necrosis and prior root canal treatment, and present with no pre-treatment pain. Outcomes focus on post-operative pain and apical healing following the procedure. The study uses standard endodontic cleaning and disinfection, with activation methods applied to enhance irrigant efficacy. Data will be collected to assess whether activation methods offer superior pain control and healing compared with conventional irrigation.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Patients older than 18 years
* Mature permanent tooth
* Pulpal diagnosis: pulp necrosis, previously initiated treatment, root filled
* Apical diagnosis: asymptomatic apical periodontitis
* Pre-operative pain of 0 on the Visual Analogue Scale (VAS)

Exclusion criteria:

* Permanent teeth with immature roots or open apices
* Teeth not eligible for orthograde (re)treatment
* Teeth with acute pain
* Teeth with periodontal pockets ≥ 5 mm
* Teeth with persistent intracanal drainage
* Non-restorable teeth
* Pregnant women
* Patients who took drugs with possible influence on the pain sensation within 12 hours before treatment
* Patients with pain from one or multiple teeth
* Patients with contra-indications for the use of NSAID
* Patients with a known or suspected malignancy
* Patients with a history of chemotherapy within five years
* Patients with a history of radiation therapy in the head and neck region
* Patients with a history of metabolic bone diseases

Where it's running

• Endo Point
  Antwerp, Belgium Recruiting
• UZ Gent
  Ghent, Belgium Recruiting

Study contacts

• Study coordinator: Mieke De Bruyne, Prof. dr.
• Email: Mieke.DeBruyne@uzgent.be
• Phone: +3293324020

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Different endodontic motor motions during root canals and their effect on pain

  This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Antalya · NCT07714733

• Two irrigation methods and activation techniques during a single-visit retreatment: does pain differ after root canal retreatment?

  This study tests whether two different irrigation approaches and activation methods change postoperative pain after a single-visit retreatment in adults with a prior root canal.

  Recruiting Phase 4 TC Erciyes University · Kayseri · NCT07599254

• i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

  This trial will see if adding injectable platelet-rich fibrin (i-PRF) to regenerative treatment helps adults 18–50 with failed root canals and periapical lesions heal better than standard non-surgical retreatment.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.