i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial enrolls adults aged 18–50 with single-rooted maxillary anterior teeth showing radiographic periapical lesions after failed root canal therapy. Participants are randomly assigned to receive either conventional non-surgical root canal retreatment or a regenerative endodontic protocol using autologous injectable platelet-rich fibrin (i-PRF). Procedures include removal of previous root fillings, chemomechanical preparation, and placement of either standard obturation or i-PRF as a biologic scaffold, with clinical exams and radiographs used to track healing. Outcomes include periapical radiographic healing, clinical signs and symptoms, tooth survival, and long-term treatment success during scheduled follow-up visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 50 years.
* Single-rooted maxillary anterior teeth with closed apices.
* Presence of periapical lesion confirmed radiographically.
* Previously treated root canal tooth requiring non-surgical retreatment.
* Tooth has not previously undergone non-surgical root canal retreatment.
* Tooth is considered restorable.
* Patient is systemically healthy.
* Patient is willing to participate and provides informed consent.

Exclusion Criteria:

* Teeth without radiographic evidence of periapical lesion.
* Teeth with developmental anomalies.
* Patients with systemic diseases that may affect healing.
* Pregnant patients.
* Teeth presenting with internal or external root resorption.

Where it's running

• Marmara University
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Melike B KAPLANOGLU
• Email: melikekaplanoglu37@gmail.com
• Phone: 905319330396

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

  This trial tests whether different methods of agitating methylene blue during antimicrobial photodynamic therapy can improve healing and reduce infection in teeth that prior root canals had treated for asymptomatic apical periodontitis.

  Recruiting Karadeniz Technical University · Trabzon, Ortahisar · NCT07921277

• Conventional and nano-metronidazole irrigation with or without ultrasonic activation for necrotic single-rooted teeth with apical periodontitis

  This study tests whether conventional metronidazole or a nano-formulated version, used as root canal irrigants with or without ultrasonic activation, can reduce post-operative pain and endotoxin levels in necrotic single-rooted teeth with apical periodontitis.

  Recruiting October 6 University · Giza, Giza Governorate · NCT07897591

• Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

  This study tests whether laser-activated irrigation or sonic activation helps reduce post-operative pain and improve healing after re-treating a tooth with persistent apical inflammation, compared to conventional needle irrigation.

  Recruiting at 2 sites University Ghent · Antwerp and 1 other locations · NCT07883486

• Different endodontic motor motions during root canals and their effect on pain

  This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Antalya · NCT07714733

• Two irrigation methods and activation techniques during a single-visit retreatment: does pain differ after root canal retreatment?

  This study tests whether two different irrigation approaches and activation methods change postoperative pain after a single-visit retreatment in adults with a prior root canal.

  Recruiting Phase 4 TC Erciyes University · Kayseri · NCT07599254

• How French dentists treat infected or non-vital baby (primary) teeth

  See how dentists in France treat children’s non-vital or infected primary teeth and what leads them to choose extraction, pulpectomy, or other options.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07297836

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.