i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment: A Clinical Study
This trial will see if adding injectable platelet-rich fibrin (i-PRF) to regenerative treatment helps adults 18–50 with failed root canals and periapical lesions heal better than standard non-surgical retreatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07448571 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial enrolls adults aged 18–50 with single-rooted maxillary anterior teeth showing radiographic periapical lesions after failed root canal therapy. Participants are randomly assigned to receive either conventional non-surgical root canal retreatment or a regenerative endodontic protocol using autologous injectable platelet-rich fibrin (i-PRF). Procedures include removal of previous root fillings, chemomechanical preparation, and placement of either standard obturation or i-PRF as a biologic scaffold, with clinical exams and radiographs used to track healing. Outcomes include periapical radiographic healing, clinical signs and symptoms, tooth survival, and long-term treatment success during scheduled follow-up visits.
Who should consider this trial
Good fit: Adults 18–50 with a single-rooted maxillary anterior tooth that is restorable, has a radiographic periapical lesion after primary root canal treatment, has not undergone prior non-surgical retreatment, and who are systemically healthy and able to consent.
Not a fit: Patients with multi-rooted teeth, developmental anomalies, internal or external root resorption, systemic diseases that impair healing, pregnancy, or no radiographic periapical lesion are unlikely to qualify or benefit from this protocol.
Why it matters
Potential benefit: If successful, i-PRF–based regenerative retreatment could improve periapical healing, better preserve tooth structure, and increase long-term tooth survival compared with conventional retreatment.
How similar studies have performed: Regenerative endodontic techniques and platelet-rich fibrin have shown promising results in case reports and small clinical series, but high-quality randomized comparisons of i-PRF versus conventional retreatment are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged between 18 and 50 years. * Single-rooted maxillary anterior teeth with closed apices. * Presence of periapical lesion confirmed radiographically. * Previously treated root canal tooth requiring non-surgical retreatment. * Tooth has not previously undergone non-surgical root canal retreatment. * Tooth is considered restorable. * Patient is systemically healthy. * Patient is willing to participate and provides informed consent. Exclusion Criteria: * Teeth without radiographic evidence of periapical lesion. * Teeth with developmental anomalies. * Patients with systemic diseases that may affect healing. * Pregnant patients. * Teeth presenting with internal or external root resorption.
Where this trial is running
Istanbul
- Marmara University — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Melike B KAPLANOGLU
- Email: melikekaplanoglu37@gmail.com
- Phone: 905319330396
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.