Risk-score predictor for dementia in older adults with depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses routinely collected clinical data from electronic medical records to build and test a point risk score for predicting dementia in older adults with depression. Researchers will calculate the score from baseline data and follow participants to see who develops dementia. No new tests or treatments are performed; data are analyzed retrospectively or prospectively from existing records. The aim is to determine if higher scores correlate with higher dementia risk and how accurately the model identifies high-risk individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged ≥50 years.
* A diagnosis of depression clearly recorded by a clinician in the electronic medical record at baseline (based on structured or unstructured diagnostic documentation formed through routine clinical practice).
* Complete baseline electronic medical record data available, including at least demographic information (age, sex), clinical diagnoses, comorbidities, and medication records.
* At least one follow-up record available in the electronic medical record system to enable determination of incident dementia outcomes.
* Informed consent provided for the use of routine medical data for this research analysis.

Exclusion Criteria:

* Any type of dementia diagnosis recorded in the electronic medical record at baseline (including Alzheimer's disease, vascular dementia, and other types of dementia).
* Medical record documentation indicating that the diagnosis of dementia preceded the diagnosis of depression, or an inability to clearly determine the chronological order of the two diagnoses.
* Presence of other neurological diseases at baseline that may independently cause severe cognitive impairment (e.g., Parkinson's disease, multiple sclerosis, brain tumor, normal pressure hydrocephalus).
* Missing key baseline electronic medical record data that would preclude subsequent risk model analysis.
* Incomplete follow-up information or inability to clearly confirm incident dementia outcomes through the electronic medical record system.
* Refusal to participate in the study or withdrawal of informed consent.

Where it's running

• Second Affiliated Hospital of Nanchang University
  Nanchang, Jiangxi, China Recruiting

Study contacts

• Study coordinator: Xi-jian Dai, PhD
• Email: daixjdoctor@126.com
• Phone: 13755756959

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.