Home-based gamma-tACS with personalized cognitive training for mild Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates a multimodal, at-home treatment that combines gamma-frequency transcranial alternating current stimulation with individualized computerized cognitive training in adults with mild Alzheimer's disease. The approach aims to entrain neural oscillations and enhance memory performance while monitoring clinical and biological markers of efficacy and potential predictors of response. Participants use a caregiver-supported protocol with sham stimulation as a control, enabling assessment of tolerability and cognitive outcomes in a real-world setting. The study references prior safety data on gamma-tACS over the precuneus and builds on cognitive rehabilitation evidence to evaluate combined effects. Primary outcomes focus on cognitive performance and related biomarkers, with exploratory analyses to identify predictors of response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients:

* Male or female participants aged ≥18 years at the time of signing the informed consent form;
* Clinical diagnosis of mild Alzheimer's disease (AD) according to current clinical criteria;
* Availability of a caregiver who can assist the participant and who has successfully completed the required training for the use of the device at home.

Caregivers:

* Male or female caregivers aged ≥18 years;
* Compliance with participation in the in-hospital training;
* Mini-Mental State Examination (MMSE) score \>27/30.

Exclusion Criteria:

* Age below that specified in the inclusion criteria;
* Inability to understand;
* Contraindications to tACS and TMS (e.g., presence of a cardiac pacemaker or metallic implants incompatible with electrical or magnetic fields, history of epilepsy, or current pregnancy, as assessed using the safety questionnaire).

Where it's running

• IRCCS Istituto Centro San Giovanni Di Dio - Fatebenefratelli
  Brescia, Brescia, Italy Recruiting
• IRCCS S. Maria Nascente - Fondazione Don Carlo Gnocchi
  Milan, Italy Not yet recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.