NIH-funded research R01 grant

Understanding why young children might hurt themselves

Official title: Longitudinal examination of emotional reactivity and reactive aggression linking threat exposure with childhood self-injurious thoughts and behaviors

Funded at Research Triangle Institute · NIH-11145811 · Data updated 2026-11-12

This project looks at how stressful experiences and strong emotions in young children connect to thoughts and actions of self-harm.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionResearch Triangle Institute
NIH-funded
Lab location1 site (Research Triangle Park, United States)
Project startSeptember 1, 2023
Project endJune 30, 2028
Funding year2025
Award (this year)$845,984
NIH project number5R01MH131565-03
Project IDNIH-11145811 on NIH RePORTER

Who could benefit from this research

Could help

This research focuses on young children who have experienced stressful or threatening situations and may be showing signs of emotional reactivity or aggression.

Less likely to help

Patients who are adults or do not have a history of threat exposure or self-injurious thoughts and behaviors may not directly benefit from this specific research.

What this research studies

The grant focuses on self-injurious thoughts and behaviors (STBs) in young children, which are often misunderstood but are a growing concern. We know that difficult or threatening experiences can increase a child's risk for STBs, possibly by making them more emotionally reactive or aggressive. This project aims to understand how these experiences lead to STBs in younger children, rather than just adolescents, by looking at how emotions and aggression develop. We also want to see if children are at higher risk for STBs right after stressful events.

Why it matters

Potential benefit: This work could help us identify young children at risk for self-harm earlier, leading to better support and prevention strategies.

How similar studies have gone: While previous research has linked threat exposure to self-harm in adolescents, this project explores these connections in younger children, which is an understudied area.

Where this research is happening

  • Research Triangle Institute
    Research Triangle Park, United States
    Active

Researchers

  • Principal investigator: Oppenheimer, Caroline — Research Triangle Institute
  • Study coordinator: Oppenheimer, Caroline

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.