Understanding how the brain controls aggression
Mapping experience-dependent change in a circuit for aggression
['FUNDING_R01'] · PRINCETON UNIVERSITY · NIH-11020966
This study is looking at how certain experiences can change the brain and lead to ongoing aggressive behavior, which could help us understand why some people with conditions like autism and bipolar disorder struggle with aggression.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11020966 on ClinicalTrials.gov |
What this research studies
This research investigates the neural mechanisms that lead to persistent high-aggression states in the brain. By examining how experiences of aggression can alter neural circuits, the study aims to uncover the biological basis for aggressive behavior in various mental health disorders. Using animal models, researchers will track changes in brain activity over time, focusing on specific areas known to regulate aggression. This approach could provide insights into how aggression becomes dysregulated in conditions like autism and bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with conditions associated with high levels of aggression, such as autism spectrum disorder or bipolar disorder.
Not a fit: Patients without any history of aggressive behavior or those not diagnosed with related mental health disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing aggression in patients with mental health disorders.
How similar studies have performed: Previous research has shown promise in understanding aggression through neural mechanisms, but this specific approach is relatively novel.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FALKNER, ANNEGRET LEA — PRINCETON UNIVERSITY
- Study coordinator: FALKNER, ANNEGRET LEA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder