Investigating how stress affects aggression in the brain
Official title: Amygdala Circuit Mechanisms for Stress-escalated Aggression
Funded at Tufts University Boston · NIH-11269353 · Data updated 2026-11-12
This study is looking at how certain brain cells might make people more aggressive after they've experienced trauma, and it hopes to find new ways to help those who struggle with this issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,976 |
| NIH project number | 4R00MH133869-03 |
| Project ID | NIH-11269353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced trauma and exhibit symptoms of aggression or PTSD.
✕Less likely to help
Patients who do not have a history of trauma or do not exhibit aggressive behavior may not benefit from this research.
What this research studies
This research focuses on understanding the brain mechanisms that lead to increased aggression following trauma. By examining specific neurons in the amygdala, particularly those that respond to stress signals, the study aims to uncover how these cells contribute to aggressive behavior. Using advanced techniques like optogenetics and calcium imaging, researchers will explore the relationship between stress and aggression, which could lead to new therapeutic approaches for individuals experiencing trauma-related aggression. Patients may benefit from insights gained into the biological basis of their behavior and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for individuals struggling with aggression related to trauma and PTSD.
How similar studies have gone: Previous research has shown promising results in understanding the neural mechanisms of aggression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Newman, Emily L — Tufts University Boston
- Study coordinator: Newman, Emily L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.