Understanding how social isolation affects aggression in the brain
Official title: Prefrontal Circuit Control of Isolation-Induced Aggression
Funded at University of Utah · NIH-11010824 · Data updated 2026-11-12
This study looks at how being socially isolated can lead to increased aggression and aims to understand how a specific part of the brain helps control this behavior, especially for older adults who may be feeling lonely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | March 6, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $486,185 |
| NIH project number | 5R01MH132822-03 |
| Project ID | NIH-11010824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who experience social isolation and exhibit aggressive behaviors.
✕Less likely to help
Patients who do not experience social isolation or aggression may not benefit from this research.
What this research studies
This research investigates the impact of social isolation on aggression, particularly focusing on how the medial prefrontal cortex (mPFC) in the brain regulates aggressive behavior. By examining genetically-defined cells in the mPFC, the study aims to uncover the mechanisms that lead to increased aggression in individuals experiencing social isolation. The research is particularly relevant in light of rising rates of aggression and violence linked to loneliness, especially among the aging population. Through this work, the researchers hope to develop targeted interventions and therapies to address these issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for aggression and violence stemming from social isolation, improving mental health outcomes for affected individuals.
How similar studies have gone: While the specific focus on the mPFC and isolation-induced aggression is novel, related research has shown success in understanding the brain's role in aggression and social behavior.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Zelikowsky, Moriel — University of Utah
- Study coordinator: Zelikowsky, Moriel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.