Condition

Acne Vulgaris clinical trials and research

• 18Clinical trials
• 6NIH research projects
• 2New in 30 days
• 11Countries

Newest Acne Vulgaris clinical trials

All recruiting trials (18)

• Nadifloxacin Plus Tretinoin vs Clindamycin Plus Tretinoin for Mild-to-Moderate Acne

  This study tests whether nadifloxacin with tretinoin cream works better than clindamycin with tretinoin cream for adults with mild-to-moderate acne.

  Recruiting Phase 4 Nishtar Medical University · Multan, Punjab Province · NCT07915648

• Topical clascoterone vs. adapalene for mild-to-moderate acne in teens and young adults

  This trial tests whether clascoterone 1% cream works as well as adapalene 0.1% cream for treating mild-to-moderate acne in people aged 12–55.

  Recruiting Pak Emirates Military Hospital · Rawalpindi, Punjab Province · NCT07883538

• Denifanstat vs placebo for moderate to severe acne in teens and adults

  This study tests whether denifanstat works safely to improve acne in people 12 and older, compared with a matching placebo.

  Recruiting at 28 sites Phase 3 Sagimet Biosciences Inc. · Bryant, Arkansas and 27 other locations · NCT07863193

• Facial skin microbiome changes during isotretinoin in moderate-to-severe acne

  This study tests how the facial skin microbiome changes in people with moderate-to-severe acne who are treated with isotretinoin, and compares them with healthy individuals.

  Recruiting Can Tho University of Medicine and Pharmacy · Can Tho · NCT07834138

• Prevalence of PMOS in women with acne at Sohag University Hospital

  This study tests how common polyendocrine metabolic ovarian syndrome (PMOS) is among women with acne who are seen at Sohag University Hospital.

  Recruiting Sohag University · Sohag · NCT07822360

• Hormonal profiles and isotretinoin response in adult women with acne

  This study tests whether baseline hormones (DHEAS, FSH, and LH) help predict how adult women with acne will respond to systemic isotretinoin.

  Recruiting Biruni University · Küçükçekmece, Istanbul · NCT07818525

• RF treatment vs topical therapy for facial acne vulgaris

  Adults with mild-to-moderate inflammatory facial acne will try either a three-session radiofrequency treatment or a daily adapalene-benzoyl peroxide gel, to see which reduces acne lesions and sebum production better.

  Recruiting Jeisys Medical Inc · Nuevo León, Monterrey · NCT07805655

• Sarecycline versus doxycycline effects on skin and gut bacteria in acne

  We will test whether treating people with acne using sarecycline or doxycycline causes different changes in the bacteria on the skin and in the gut.

  Recruiting Phase 4 Integrative Skin Science and Research · Sacramento, California · NCT07544251

• Topical Cabtreo in kids aged 9 to under 12 with moderate to severe acne

  This study tests a topical cabtreo lotion in children aged 9 to 11 years 11 months to see if it is safe and can help clear moderate to severe facial and some trunk acne.

  Recruiting at 14 sites Phase 4 Bausch Health Americas, Inc. · Bryant, Arkansas and 14 other locations · NCT07524946

• 0.5% Timolol drops versus IPL for treating red marks left by acne (post‑inflammatory erythema)

  This will test whether applying 0.5% timolol eye drops to the skin can reduce the red marks left after acne in people age 12 and older, compared with intense pulsed light (IPL).

  Recruiting Early Phase 1 Pham Ngoc Thach University of Medicine · Ho Chi Minh City · NCT07474883

• Cold atmospheric plasma treatment for moderate-to-severe acne

  This trial will test two cold atmospheric plasma devices to see if they safely reduce acne in adults aged 18–40 with moderate-to-severe acne.

  Recruiting Shenyang Medical College · Luoyang, Henan · NCT07056673

• Catestatin levels in moderate-to-severe acne

  This test will measure blood levels of the peptide catestatin in people with moderate to severe acne who are treated with isotretinoin.

  Recruiting Aswan University · Aswān · NCT07054398

• Dihydroartemisinin for treating acne vulgaris

  This study will test whether taking dihydroartemisinin every day for three months can reduce acne severity in adults with acne vulgaris.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07007078

• New antiandrogenic progestogen with low-dose estrogen for moderate facial acne in women

  This Phase 3 trial tests a fixed-dose combo of cyproterone acetate and ethinyl estradiol against placebo to see if it improves moderate facial acne in women over six 28-day cycles, in addition to standard skincare.

  Recruiting at 18 sites Phase 3 Eurofarma Laboratorios S.A. · Salvador, Estado de Bahia and 17 other locations · NCT06905210

• Comparing Isotretinoin to Standard Care for Moderate Acne in Skin of Color

  This study is testing whether the acne medication isotretinoin works better than standard treatments for young people with moderate acne and skin of color.

  Recruiting at 17 sites Phase 3 Centre Hospitalier Universitaire de Nice · Nice, Alpes-Maritimes and 18 other locations · NCT06447480

• Testing clascoterone cream for treating facial acne

  This study is testing if a new clascoterone cream can help people aged 12 and older with moderate to severe facial acne improve their skin over 12 weeks.

  Recruiting Phase 3 Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd. · Shanghai · NCT06403501

• Comparing weekly Isotretinoin to daily Tetracycline for moderate acne treatment

  This study is testing if taking Isotretinoin once a week works better than taking Doxycycline every day for treating moderate acne in people aged 12 and older.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06225570

• Effects of topical erythromycin and clindamycin on acne

  This study is testing whether using both erythromycin and clindamycin creams can help people with acne clear their skin better than using just one of the treatments.

  Recruiting Phase 4 Centre for Human Drug Research, Netherlands · Leiden · NCT03883269

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Novel endolysins to target Cutibacterium acnes for acne treatment

  A small research grant is developing a highly specific enzyme therapy to kill the acne-causing bacteria without disturbing good skin or gut bacteria.

  NIH research Topaz Biosciences, INC. · Emeryville, United States · NIH-11381883

• Th17 extracellular traps and skin bacteria in acne health

  A study in people with acne aims to understand how specific skin bacteria and immune cells interact to fight acne-causing germs and how this could lead to better treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11374876

• New bacteria-targeting enzymes to fight acne

  Developing species-specific enzymes to remove the acne-causing bacterium Cutibacterium acnes for people with acne.

  NIH research Topaz Biosciences, INC. · Emeryville, United States · NIH-11183989

• Understanding the Immune System's Role in Acne

  This research explores how our body's immune cells fight the bacteria that cause acne, hoping to find new ways to treat it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11123418

• Understanding how immune responses affect acne treatment

  This study is looking at how certain immune cells and bacteria related to acne work together, with the goal of finding new ways to help treat acne and improve skin health for people who struggle with it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11122440

• Understanding how immune responses affect acne

  This study is looking at how certain immune cells in your skin interact with the bacteria that causes acne, to find out how they can help clear up breakouts or make them worse, with the hope of discovering new ways to treat acne more effectively.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10880415

Quick answers

How many Acne Vulgaris clinical trials are recruiting right now?

18, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (4 trials), China (3 trials), Egypt (2 trials), Pakistan (2 trials), Vietnam (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 4: 4, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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