Catestatin levels in moderate-to-severe acne

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Acne vulgaris is a common inflammatory condition driven by sebum, keratinization changes, and inflammatory mediators. This interventional program enrolls people with moderate to severe acne who will receive standard oral isotretinoin while investigators measure serum catestatin levels at baseline and during treatment. Participants with pregnancy, lactation, recent systemic acne therapy, immunocompromise, or certain comorbidities are excluded. The work is conducted at Aswan University Hospital and aims to link catestatin patterns with acne severity and treatment course.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy persons of both sexes with moderate and severe acne.

Exclusion Criteria:

* Pregnant and lactating women.
* Immunocompromised patients.
* Severe anemia.
* History of chronic liver disease.
* Hyperlipidemia
* Non-inflammatory acne conditions.
* History of neurologic disorders.
* History of neoplastic disorders.
* History of cardiac disease.
* History of systemic acne treatment for at least 4 weeks prior to inclusion and no topical treatments for at least 2 weeks.
* Cases with known hypersensitivity reaction to isotretinoin.

Where it's running

• Aswan Unuversity Hospital
  Aswān, Egypt Recruiting

Study contacts

• Study coordinator: Mona Zakaria Mohamed, MSc
• Email: mona1704213@aswu.edu.eg
• Phone: +201142550119

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.