Nadifloxacin Plus Tretinoin vs Clindamycin Plus Tretinoin for Mild-to-Moderate Acne
Official title: Comparison of Efficacy of Topical Nadifloxacin With Tretinoin Versus Clindamycin With Tretinoin in Mild-to-Moderate Acne.
Run by Nishtar Medical University · NCT07915648 · Data updated 2026-11-12
This study tests whether nadifloxacin with tretinoin cream works better than clindamycin with tretinoin cream for adults with mild-to-moderate acne.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 158 (estimated) |
| Sponsor | Nishtar Medical University Academic / other |
| Locations | 1 site (Multan, Punjab Province) |
| Status | Recruiting |
| Started | September 17, 2026 |
| Main results expected | March 16, 2027 |
| Study ends | March 16, 2027 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT07915648 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–40 with newly diagnosed mild-to-moderate acne vulgaris who have not used conflicting acne therapies or contraindicated conditions.
✕Probably not a fit
Patients with acne forms not responsive to topical therapy or who experience intolerable adverse effects from either medication may see limited benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, phase 4 trial compares two topical combination therapies for mild-to-moderate acne vulgaris in adults aged 18 to 40. Participants are randomly assigned to receive either nadifloxacin 1% plus tretinoin 0.025% cream or clindamycin 1% plus tretinoin 0.025% cream, applied once daily as a thin layer. The study is conducted at Nishtar Medical University and Hospital in Multan, with allocation concealed by sealed opaque envelopes. Exclusion criteria include drug-induced acne, endocrine disorders like PCOS, other facial skin diseases, pregnancy or lactation, chronic systemic illnesses, or hypersensitivity to the study medications. The trial aims to determine if the nadifloxacin combination provides superior or different efficacy and safety compared with the clindamycin combination in this patient population.
Why it matters
Potential benefit: If successful, the nadifloxacin combination could offer an effective alternative option for managing mild-to-moderate acne with a favorable safety profile.
How similar studies have gone: Previous topical antibiotic–retinoid combinations have shown benefit in acne management, but direct head-to-head data between nadifloxacin and clindamycin with tretinoin are limited in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * newly diagnosed with acne vulgaris * mild to moderate severity Exclusion Criteria: * Drug induced acne or acneiform eruptions (corticosteroids, antiepileptics, lithium, iodides) * endocrine disorders (PCOS, Cushing syndrome, congenital adrenal hyperplasia) * chronic dermatological conditions affecting face (Rosacea, seborrheic dermatitis, perioral dermatitis) * pregnant or lactating women * chronic systemic illness (chronic liver disease, kidney disease) * patients with known hypersensitivity to study medications
Where it's running
-
Nishtar Medical University and Hospital
Multan, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Muhammad T Suleman, MBBS
- Email: talha.cascade@gmail.com
- Phone: +92 331 7291061
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.