Prevalence of PMOS in women with acne at Sohag University Hospital

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional observational study aims to estimate the prevalence of PMOS in female patients aged 15 to 49 with acne vulgaris at Sohag University Hospital. Participants will be clinically evaluated for acne and screened for PMOS based on established diagnostic criteria, after excluding other causes. PMOS diagnosis requires at least two of the following: ovulatory dysfunction, hyperandrogenism clinically or biochemically, with other etiologies ruled out. The study will use standard clinical and laboratory assessments to determine PMOS presence and prevalence within the Acne vulgaris population. No interventions are implemented; findings will describe associations between acne and PMOS in this setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients at childbearing age ( 15 - 49 years) (World Health, 2024).
* Patients clinically diagnosed with acne vulgaris.

  • Clinical diagnosis of Acne vulgaris:

  o Presence of comedones (open/black and closed/white), inflammatory lesions (papules, pustules, or nodules), with or without post-acne changes such as hyperpigmentation or scarring (Oge et al., 2019).
* Patients diagnosed with polyendocrine metabolic ovarian syndrome (PMOS) according to the 2023 International Evidence-based Guideline for PCOS diagnosis.
* Diagnostic criteria for PMOS diagnosis in adults : (Forslund et al., 2024).

  * Diagnosis of PMOS will be based on the presence of at least two of the following three criteria after exclusion of other etiologies:

    1\. Ovulatory dysfunction:
    * Irregular menstrual cycles or oligo/anovulation. 2. Clinical and/or biochemical hyperandrogenism:
    * Clinical signs such as hirsutism and/or acne, or biochemical evidence of elevated androgen levels.

      3\. Polycystic ovarian morphology (PCOM):
    * Polycystic ovaries detected by pelvic ultrasound, or elevated anti-Müllerian hormone (AMH) level in adults as an alternative to ultrasound.
  * Most women with PMOS have a combination of hyperandrogenism and irregular cycles, and in these cases there is no need to assess PCOM. In adolescents, both ovulatory dysfunction and hyperandrogenism are mandatory (Forslund et al., 2024).
* Patients willing to participate and provide informed consent.

Exclusion Criteria:

* Pregnant women.
* Lactating mothers
* Women diagnosed with other acneiform lesions
* Women on certain drug treatments like oral contraceptive pills, ovarian stimulating drugs and oral hypoglycemic agents like metformin.
* Patients with incomplete clinical data or who refuse to participate in the study.

Where it's running

• Sohag university hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Omar Shazly Saleh, Resident
• Email: oshazly399@gmail.com
• Phone: +201004861933

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.