Cold atmospheric plasma treatment for moderate-to-severe acne

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will be assigned to receive one of two self-developed cold atmospheric plasma (CAP) devices, a sham CAP procedure, or standard care per JAAD acne guidelines to compare outcomes. Treatments and follow-up visits will take place at a single center in Luoyang, Henan, with efficacy measured by lesion counts and severity scales and safety monitored by adverse event reporting. Key exclusions include pregnancy or breastfeeding, recent systemic antibiotic use, known CAP allergy, dyslipidemia, or other serious systemic illnesses, and recent participation in other trials. The trial aims to compare lesion reduction and tolerability between active CAP, sham treatment, and guideline-directed therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18-40 years;
* Clinically diagnosed with acne vulgaris, with moderate to severe disease (Pillsbury grade III or IV, lesion count ≥50);
* Will agree to use effective contraception during the treatment period;
* Will sign a written informed consent form.

Exclusion Criteria:

* Pregnant or breastfeeding women;
* Known allergy to any active component of CAP;
* Use of systemic antibiotics within 4 weeks prior to enrollment;
* Presence of dyslipidemia or other severe systemic diseases;
* Participation in other clinical trials within the past 3 months or currently enrolled in another clinical trial.

Where it's running

• the 989th Hospital of Chinese People's Liberation Army Joint Logistic Support Force
  Luoyang, Henan, China Recruiting

Study contacts

• Principal investigator: Lin Tao, MM — Shenyang Medical College
• Study coordinator: Yun-En Liu, MD
• Email: lye9901@163.com
• Phone: 86-24-62215130

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.