Full-thickness vs progressive myotomy in POEM for achalasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized phase II trial compares two POEM techniques for achalasia: a full-thickness myotomy involving all muscle layers versus a progressive approach that begins with proximal circular muscle and extends distally to a full-thickness cut. Participants are adults with type 1 or type 2 achalasia confirmed by manometry and Eckardt score greater than 3, who are fit for anesthesia. The study will evaluate efficacy, incidence of post-procedural GERD, and other safety outcomes to determine which technique offers better symptom relief and acceptable safety. Conducted at Cairo University and Theodore Bilharz Institute, the trial aims to clarify optimal myotomy depth during POEM. Results could influence standard practice for POEM in achalasia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Achalasia confirmed by manometry
* Type 1 and type 2 Achalasia
* Eckhart score \>3
* Fit to undergo anaesthesia

Exclusion Criteria:

* Type 3 achalasia and other esophageal motility Disorders
* Hiatus hernia
* Coagulopathy

Where it's running

• Cairo University
  Cairo, Egypt Recruiting
• Theodore Bilharz Institute
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hany Shehab
• Email: h.shehab@kasralainy.edu.eg
• Phone: +201111111071

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Indocyanine green fluorescence during laparoscopic Heller–Dor for achalasia

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.