PRECISION MEDICINE IN ACHALASIA: PREMEDIA
Official title: PREcision MEDicine In Achalasia--PREMEDIA
Funded at Northwestern University · NIH-11416283 · Data updated 2026-11-12
A patient-centered project to understand and improve treatments for achalasia and related esophageal disorders using precise, tailored approaches.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 18, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,477,081 |
| NIH project number | 5U01DK142700-02 |
| Project ID | NIH-11416283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with achalasia or related esophageal motility disorders who are candidates for POEM or other endoscopic therapies.
✕Less likely to help
Patients not undergoing POEM or related procedures or those who decline participation.
What this research studies
This research aims to unravel how different POEM techniques affect outcomes for people with achalasia. It will collect and analyze patient data and biological samples to refine when and how to use POEM, with a focus on safety, effectiveness, and quality of life. Participants may contribute information about symptoms, procedures, and recovery to help tailor future treatments to individual needs.
Why it matters
Potential benefit: Could lead to more effective, personalized treatments for achalasia and fewer complications.
How similar studies have gone: Previous work shows POEM can be effective, but understanding optimal techniques is still evolving.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Pandolfino, John E — Northwestern University
- Study coordinator: Pandolfino, John E
Related research
Other NIH-funded projects on the same topics.
-
Immune Mechanisms Behind Achalasia
This grant looks at how the immune system may drive achalasia and scarring in the esophagus, with findings possibly guiding new treatments for patients.
-
Investigating the role of fibrosis in the lower esophageal sphincter for achalasia patients
This study is looking at how thickening and scarring of muscle tissue affects swallowing in people with achalasia, and it aims to find new treatment options to help improve their condition.
-
Improving treatment for achalasia using a new endoscopic technique
This study is looking at a new procedure called POEM to see how well it helps people with achalasia, a condition that makes swallowing difficult, and it will compare different techniques to find the best way to improve treatment for patients.
-
Full-thickness vs progressive myotomy in POEM for achalasia
This trial tests whether a full-thickness myotomy during POEM works better than a partial, progressive approach for people with achalasia, to see which method better relieves symptoms with fewer side effects.
-
Impact of Patient Position on EndoFLIP Measurements in Kids and Young Adults
This study tests whether EndoFLIP measurements differ when patients are in the supine versus left-side position during the procedure.
-
A registry for adults with esophageal movement and reflux problems.
This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.