['FUNDING_FELLOWSHIP'] ·
MAGEE-WOMEN'S RES INST AND FOUNDATION ·
NIH-11055962
This study is looking at a new gene therapy using a virus to help treat male infertility caused by problems with Sertoli cells, specifically for men who have a condition called non-obstructive azoospermia, and it aims to find a safe and effective way to restore sperm production.
Why this is a good match: Targets Sertoli-cell dysfunction to restore spermatogenesis in NOA
PHASE1; PHASE2 ·
Stem Cells Arabia ·
NCT02641769
This study tests whether a patient’s own bone marrow–derived stem cells, prepared to become sperm-supporting cells, can be injected into the testis to see if sperm production can resume in men with non-obstructive azoospermia.
Why this is a good match: Autologous stem cell injection aims to resume sperm production in NOA
Conditions:
Non-obstructive Azoospermia
NA ·
Brigham and Women's Hospital ·
NCT07074015
This will try an AI-assisted imaging platform to find rare sperm in testicular samples from men with non-obstructive azoospermia when standard processing finds no sperm.
Why this is a good match: AI-assisted imaging to find rare sperm when standard processing fails
Conditions:
Infertility, Azoospermia, infertility, azoospermia, micro-TESE
['FUNDING_R01'] ·
BRIGHAM AND WOMEN'S HOSPITAL ·
NIH-11322720
An AI-powered lab tool that looks for and helps retrieve tiny numbers of sperm to help men with very low sperm counts or azoospermia try for biological children.
Why this is a good match: AI-powered lab tool to detect and retrieve tiny sperm numbers
['FUNDING_OTHER'] ·
COLUMBIA UNIVERSITY HEALTH SCIENCES ·
NIH-11456661
A new AI-guided device helps doctors find and recover extremely rare sperm from men with azoospermia to enable potential fertility treatments.
Why this is a good match: AI-guided device designed to locate and recover extremely rare sperm
NA ·
Wake Forest University Health Sciences ·
NCT04298255
This study is testing a new way to help couples with male infertility by using special cells called round spermatids to see if they can successfully fertilize eggs and lead to pregnancy.
Why this is a good match: Assesses round spermatid injection as alternative fertilization for azoospermia
Conditions:
Infertility, Male, IVF, Fertility
PHASE1; PHASE2 ·
CellARTs Inc. ·
NCT06841861
This study is testing if scientists can create human sperm in a lab using special tissue samples from men to help understand and treat male infertility.
Why this is a good match: Seeks to create human sperm in vitro from patient tissue samples
Conditions:
Infertility, Male, Gene Abnormality, Sterility, Male
['FUNDING_OTHER'] ·
UNIVERSITY OF CALIFORNIA, SAN DIEGO ·
NIH-11463096
A new non-invasive semen test aims to tell men with infertility whether testicular sperm can be retrieved to support IVF.
Why this is a good match: Non-invasive semen test predicts likelihood of retrieving testicular sperm
NA ·
Hadassah Medical Organization ·
NCT02418832
This study tests if a special needle procedure can help men with no sperm in their semen produce sperm from their testis for use in fertility treatments.
Why this is a good match: Tests needle procedure to obtain sperm from testis for ART
Conditions:
Azoospermia, Rete Testis, TEFNA
NA ·
Stanford University ·
NCT05479474
This study is testing if using platelet-rich plasma injections can help men with infertility, specifically those who have had trouble retrieving sperm, improve their chances of successful sperm extraction and IVF.
Why this is a good match: Platelet-rich plasma injections aim to improve sperm retrieval success
Conditions:
Male Infertility, Nonobstructive Azoospermia, Azoospermia
The Third Affiliated Hospital of Guangzhou Medical University ·
NCT07691827
Researchers look at whether a mitochondrial MT-ND1 variant inherited from mothers is linked to very low or absent sperm production in men with idiopathic infertility.
Why this is a good match: Investigates mitochondrial MT-ND1 variant linked to absent sperm production
Conditions:
Azoospermia, Nonobstructive, Cryptozoospermia, Male Infertility, MT-ND1, Maternal Inheritance
PHASE1; PHASE2 ·
Lomonosov Moscow State University Medical Research and Educational Center ·
NCT06869863
This study is testing a new treatment called MediReg® to see if it can help men with severe infertility issues improve their sperm quality and increase their chances of conceiving.
Why this is a good match: Tests MediReg® to potentially improve sperm quality in severe infertility
Conditions:
Azoospermia, Nonobstructive, Teratospermia, Oligospermia, Men Infertility, men infertility
Shady Grove Fertility Reproductive Science Center ·
NCT06941922
This study is testing if a special type of ultrasound can help doctors see differences in the tiny tubes in the testicles of men with no sperm and help figure out why that’s happening.
Why this is a good match: Ultrasound aims to visualize seminiferous tubule differences in azoospermia
Conditions:
Azoospermia, azoospermia, infertility, microultrasound, microdissection
['FUNDING_R01'] ·
OREGON HEALTH & SCIENCE UNIVERSITY ·
NIH-11133006
This research helps us understand the genetic reasons why some men experience severe infertility, aiming to improve diagnosis and care.
Why this is a good match: Researches genetic reasons for severe male infertility aiding diagnosis
Conditions:
Cancers, Cardiovascular Diseases
National Institutes of Health Clinical Center (CC) ·
NCT07357701
This project will collect DNA from adults with NOA, oligospermia, or POI to try to find gene changes that may cause their infertility.
Why this is a good match: Collects DNA from NOA patients to find causative gene changes
Conditions:
Primary Ovarian Insufficiency, Azoospermia, Oligospermia, NOA, POI
['FUNDING_OTHER'] ·
UNIVERSITY OF PITTSBURGH AT PITTSBURGH ·
NIH-11400046
This grant aims to uncover the genetic causes of male infertility (azoospermia) to improve diagnosis and pave the way for personalized treatments.
Why this is a good match: Aims to uncover genetic causes of azoospermia for personalized care
Conditions:
Cancers
['FUNDING_SBIR_2'] ·
INHERENT BIOSCIENCES, INC. ·
NIH-11026097
This study is looking to create a new test that helps men with severe infertility, especially those with a condition called Non-Obstructive Azoospermia, by understanding the genetic factors that might affect their health and fertility, so they can get better support and treatment options.
Why this is a good match: Develops genetic test to support NOA patient health and fertility care
['FUNDING_FELLOWSHIP'] ·
UNIVERSITY OF UTAH ·
NIH-11082973
This study is looking at how certain genetic changes might be linked to male infertility and overall health, and it's for men who are interested in understanding how their genes could affect their fertility and risk for health issues like cancer and heart disease.
Why this is a good match: Studies links between genetic changes and male infertility and health risks
['FUNDING_R01'] ·
BAYLOR COLLEGE OF MEDICINE ·
NIH-11223320
This project uses long-read DNA sequencing to find genes and mutations that may cause infertility in men.
Why this is a good match: Uses long-read sequencing to find mutations causing male infertility
['FUNDING_R01'] ·
WAYNE STATE UNIVERSITY ·
NIH-11260154
This project tests whether measuring mitochondrial DNA in sperm can help predict fertility and the chances of conception or treatment success for men trying to father children.
Why this is a good match: Evaluates mitochondrial DNA measures to predict fertility treatment success