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Clinical trial Recruiting at 1 site Interventional Ages 18 and up Men only

Using platelet rich plasma to treat infertility in men

Official title: Platelet Rich Plasma Testis

Run by Stanford University · NCT05479474 · Data updated 2026-11-12

This study is testing if using platelet-rich plasma injections can help men with infertility, specifically those who have had trouble retrieving sperm, improve their chances of successful sperm extraction and IVF.

Quick facts

Study typeInterventional
Ages18 Years and up
SexMen only
Enrollment10 (estimated)
SponsorStanford University
Academic / other
Locations1 site (Stanford, California)
StatusRecruiting
StartedJanuary 18, 2023
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJanuary 13, 2026
Trial IDNCT05479474 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are men over the age of 18 diagnosed with nonobstructive azoospermia who have experienced at least one failed sperm retrieval attempt.

Probably not a fit

Patients who have not been diagnosed with nonobstructive azoospermia or those who have not undergone a failed sperm retrieval procedure may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of intratesticular injections of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in men suffering from infertility, specifically those with nonobstructive azoospermia who have previously undergone a failed sperm retrieval. The approach aims to determine if PRP can enhance the outcomes of testicular sperm extraction (TESE) procedures. By focusing on a population with limited treatment options after negative sperm retrieval attempts, the study seeks to provide new insights into potential fertility treatments.

Why it matters

Potential benefit: If successful, this treatment could significantly improve sperm retrieval rates and fertility outcomes for men with nonobstructive azoospermia.

How similar studies have gone: While the approach of using PRP for fertility treatments is relatively novel, prior series have suggested potential improvements in TESE outcomes, indicating a promising avenue for further investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Men over the age of 18 diagnosed with NOA and at least one failed TESE, negative mapping or negative biopsy

Exclusion Criteria:

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Where it's running

  • Stanford Urology Clinic
    Stanford, California, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Male Infertility 24Azoospermia 6Stanford University 2512
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.