Condition
Primary Ovarian Insufficiency clinical trials and research
As of November 12, 2026, Find a Trial lists 5 Primary Ovarian Insufficiency clinical trials that are recruiting, at sites in 3 countries (most in United States (3), Hungary (1), Italy (1)). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 5Clinical trials
- 3Countries
Newest Primary Ovarian Insufficiency clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Identifying genetic variants in non-obstructive azoospermia and primary ovarian insufficiency | — | Bethesda, Maryland and 1 other locations | Recruiting | Jan 22, 2026 |
| Estrogen therapy and heart health in women with POI | — | Boston, Massachusetts | Recruiting | Mar 10, 2025 |
| Comparing progesterone options for endometrial protection in young women on estrogen therapy | — | Aurora, Colorado | Recruiting | Apr 10, 2024 |
| Investigating mitochondrial dysfunction in women with PCOS and infertility | — | Budapest | Recruiting | Dec 12, 2023 |
| Investigation of genetic factors in primary ovarian insufficiency | — | Genova | Recruiting | Apr 14, 2022 |
All recruiting trials (5)
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Identifying genetic variants in non-obstructive azoospermia and primary ovarian insufficiency
This project will collect DNA from adults with NOA, oligospermia, or POI to try to find gene changes that may cause their infertility.
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Estrogen therapy and heart health in women with POI
This study tests whether starting estrogen replacement helps heart-health markers in women newly diagnosed with POI compared with healthy peers.
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Comparing progesterone options for endometrial protection in young women on estrogen therapy
This study is testing whether oral progesterone or a hormone implant is better at protecting the uterus in young women who are taking estrogen therapy.
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Investigating mitochondrial dysfunction in women with PCOS and infertility
This study is trying to see if problems with energy production in cells are linked to polycystic ovary syndrome (PCOS) and infertility in women.
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Investigation of genetic factors in primary ovarian insufficiency
This study is trying to find out if certain genes play a role in primary ovarian insufficiency in women diagnosed before age 38, to improve future testing and treatment options.
Related topics
Quick answers
How many Primary Ovarian Insufficiency clinical trials are recruiting right now?
5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (3 trials), Hungary (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.