Motor learning with physical activity and advanced devices in healthy people and movement disorders
Official title: Motor Planning, Execution, and Modulation in Healthy Individuals and Patients With Movement Disorders or Neuromuscular Diseases Using Traditional Physical Activity or Advanced Devices to Enhance Motor Learning and Sensorimotor Processing
Run by IRCCS Centro Neurolesi Bonino Pulejo · NCT07066137 · Data updated 2026-11-12
This study tests whether combining traditional physical activity with advanced devices and immersive therapy helps improve motor skills and functional recovery in healthy individuals and people with movement disorders.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | IRCCS Centro Neurolesi Bonino Pulejo Academic / other |
| Locations | 1 site (Messina, Italy/Me) |
| Status | Recruiting |
| Started | May 5, 2024 |
| Main results expected | December 6, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT07066137 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with healthy status or diagnosed movement disorders (Parkinson’s, MS) or cognitive conditions (Alzheimer’s, dementia) who meet MoCA ≥ 20 and can participate in intensive training.
✕Probably not a fit
Individuals unable to participate in intensive training or with severe medical/psychiatric conditions may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial intercedes with both conventional physical training and innovative technologies to explore motor responses and brain activity in healthy participants and patients with Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, or dementia. It uses tools like CAREN, TMS, tDCS, ultrasound/laser therapy, cryotherapy, and music therapy, along with proprioceptive and visuo-cognitive-motor stimulation to examine changes in motor performance and neural activation. Outcomes include motor gesture control, spatial-temporal brain activity during training, and strategies to improve balance and quality of life. Multimodal data from imaging and psychometrics will inform personalized rehabilitation approaches.
Why it matters
Potential benefit: If successful, participants could see improved motor function and better quality of life through tailored rehabilitation strategies.
How similar studies have gone: Prior studies have shown benefits of combining physical rehab with neuromodulation and virtual reality approaches in motor recovery.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Montreal Cognitive Assessment (MoCA) score (adjusted for age and education) equal to or greater than 20. Exclusion Criteria: * Severe medical and psychiatric disorders potentially affecting the training
Where it's running
-
IRCCS Centro Neurolesi Bonino Pulejo
Messina, Italy/Me, Italy Recruiting
Study contacts
- Study coordinator: Maria Grazia Maggio, Phd
- Email: mariagrazia.maggio@irccsme.it
- Phone: +3909061128250
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.