Knife-assisted full-thickness resection for rectal lesions in a multicenter setting
Official title: Outcomes of Endoscopic Knife-Assisted Full-Thickness Resection for Rectal Lesions: An International Multicentre Retrospective Cohort Study
Run by University Hospital, Ghent · NCT07923682 · Data updated 2026-11-12
A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University Hospital, Ghent Academic / other |
| Locations | 1 site (Ghent) |
| Status | Recruiting |
| Started | May 2, 2025 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07923682 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who underwent kFTR for a rectal lesion at a participating center.
✕Probably not a fit
Patients with unsuitable lesion characteristics or incomplete data may not benefit from this technique.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational study collects data from patients who had knife-assisted full-thickness resection (kFTR) for rectal lesions. The researchers look at technical success, whether the lesion was removed in one piece with clean margins, and complication rates, including bleeding and post-procedure issues. Secondary outcomes include hospital stay, need for additional surgery, cancer recurrence, and death. Data are drawn from participating centers to describe real-world performance of kFTR for early rectal cancers.
Why it matters
Potential benefit: If successful, kFTR could offer a safe, effective, organ-preserving option for select rectal lesions.
How similar studies have gone: Previous small studies suggest potential for organ-preserving resection techniques, but large-scale evidence for kFTR is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older * Knife-assisted full-thickness resection (kFTR) performed for a rectal lesion at a participating center Exclusion Criteria: * Unavailable information regarding kFTR technical outcomes
Where it's running
-
University Hospital Ghent
Ghent, Belgium Recruiting
Study contacts
- Principal investigator: David Tate — University Hospital, Ghent
- Study coordinator: David Tate
- Email: studiestissue.resectie@uzgent.be
- Phone: 093321063
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.