Clinical trial Recruiting at 1 site Observational Ages 18 and up

Knife-assisted full-thickness resection for rectal lesions in a multicenter setting

Official title: Outcomes of Endoscopic Knife-Assisted Full-Thickness Resection for Rectal Lesions: An International Multicentre Retrospective Cohort Study

Run by University Hospital, Ghent · NCT07923682 · Data updated 2026-11-12

A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorUniversity Hospital, Ghent
Academic / other
Locations1 site (Ghent)
StatusRecruiting
StartedMay 2, 2025
Main results expectedDecember 31, 2029
Study endsDecember 31, 2029
Registry record updatedNovember 6, 2026
Trial IDNCT07923682 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) who underwent kFTR for a rectal lesion at a participating center.

Probably not a fit

Patients with unsuitable lesion characteristics or incomplete data may not benefit from this technique.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study collects data from patients who had knife-assisted full-thickness resection (kFTR) for rectal lesions. The researchers look at technical success, whether the lesion was removed in one piece with clean margins, and complication rates, including bleeding and post-procedure issues. Secondary outcomes include hospital stay, need for additional surgery, cancer recurrence, and death. Data are drawn from participating centers to describe real-world performance of kFTR for early rectal cancers.

Why it matters

Potential benefit: If successful, kFTR could offer a safe, effective, organ-preserving option for select rectal lesions.

How similar studies have gone: Previous small studies suggest potential for organ-preserving resection techniques, but large-scale evidence for kFTR is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged 18 years and older
* Knife-assisted full-thickness resection (kFTR) performed for a rectal lesion at a participating center

Exclusion Criteria:

* Unavailable information regarding kFTR technical outcomes

Where it's running

  • University Hospital Ghent
    Ghent, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.