New ceramide‑and‑coconut‑oil skin barrier cream versus petrolatum for dry or irritated skin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized controlled trial compares a novel topical barrier product (containing ceramides, cholesterol, virgin coconut oil, and monolaurin) with petrolatum in adults who have mild-to-moderate skin barrier dysfunction. Participants will apply the assigned product twice daily to symmetrical forearm sites for 28 days and attend weekly clinic visits for measurements. Primary outcomes are objective measures of barrier function and skin condition—transepidermal water loss (Tewameter), skin hydration (Corneometer), skin lipids (Sebumeter), and erythema/pigmentation (Mexameter)—collected at baseline and weeks 1, 2, and 4. Secondary outcomes include patient-reported dryness and itch on visual analogue scales, treatment comfort and satisfaction, and monitoring of adverse skin reactions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of mild skin barrier dysfunction, including:
* Mild to moderate atopic dermatitis, defined as SCORAD ≤ 50, and/or not currently requiring topical corticosteroids or immunomodulators.
* Mild to moderate chronic plaque psoriasis, defined as total body surface area (BSA) involved: ≤3% to 10%.
* Contact dermatitis
* Seasonal xerosis or clinically evident skin dryness
* Symmetrical or bilateral test areas available (volar forearm)
* Willing and able to provide informed consent and adhere to study procedures

Exclusion Criteria:

* Failure to meet any of the above inclusion criteria
* Severe atopic dermatitis or psoriasis requiring systemic or high-potency topical treatment
* Use of corticosteroids, calcineurin inhibitors, biologics, or phototherapy within 2 weeks
* Open wounds or evidence of secondary infection at test sites
* Pregnant or breastfeeding women
* Multiple nevi, tattoos, dense body hair in the test areas
* Debilitated or immunocompromised subjects
* Known or suspected hypersensitivity to the interventional product (or its ingredients) or petrolatum
* Refusal or failure to comply with the schedule of visits at the test site.

Where it's running

• VMV Skin Research Center & Clinics
  Makati City, National Capital Region, Philippines Recruiting

Study contacts

• Principal investigator: Vermen M Verallo Rowell, MD — VMV Skin Research Center & Clinics
• Study coordinator: Cristina C Verallo Rowell, MD, MBA
• Email: ccvrowell@gmail.com
• Phone: 639171478318

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.