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Clinical trials and research at University of Toronto

• 31Clinical trials
• 14NIH research projects
• 2Countries

Newest trials

All recruiting trials (31)

• Does pre-exercise nutrition change sex differences in fuel use during endurance cycling

  This study tests whether having carbohydrates, protein, or nothing before exercise affects how men and women burn fuel during 90 minutes of cycling and a performance test.

  Recruiting University of Toronto · Toronto, Ontario · NCT07829237

• Video education added to nutrition programs to lower type 2 diabetes risk

  A video about nutrition and diabetes is being tested with Seva Food Bank participants to see if it improves diet quality and diabetes risk factors.

  Recruiting University of Toronto · Mississauga, Ontario · NCT07790081

• ADAPT: a new parenting program to help depressed parents improve their kids’ behavior

  A new parenting program called ADAPT tests whether tailored support for parents with depression helps reduce their child’s emotional and behavioral problems better than the standard Incredible Years Parenting Program.

  Recruiting University of Toronto · Toronto, Ontario · NCT07749521

• Habit-based plan to cut sitting time in cancer survivors

  This study tests a remote 8-week habit-based program to reduce daily sedentary time in adults who have completed cancer treatment.

  Recruiting University of Toronto · Toronto, Ontario · NCT07694479

• REFLECT: Group compassion-focused cognitive behavioral therapy for core beliefs in psychosis

  This 6-week online group program will test whether compassion-focused CBT that targets core beliefs helps adults with schizophrenia-spectrum psychosis.

  Recruiting University of Toronto · Scarborough Village, Ontario · NCT07569471

• Different exercise programs during perimenopause

  Over six weeks, this trial will try following Health Canada exercise guidelines, doing high-intensity interval training (HIIT), or doing stretching to see which is easiest and most enjoyable for women in perimenopause who have menopause symptoms.

  Recruiting University of Toronto · Toronto, Ontario · NCT07132385

• Intrathecal morphine and urinary retention after revision knee replacement

  This study will see if adding a small dose of spinal (intrathecal) morphine for adults having revision knee replacement lowers early pain but raises the chance of needing a urinary catheter.

  Recruiting Phase 3 University of Toronto · Toronto, Ontario · NCT07050277

• Mobile prompts and education to reduce jaw clenching and awake bruxism

  This trial tests whether a one-week mobile prompt program combined with an educational video helps adults with temporomandibular disorder (TMD) or awake bruxism reduce jaw clenching and masticatory muscle activity compared with education alone.

  Recruiting University of Toronto · Toronto, Ontario · NCT07022795

• Observing how EPA is metabolized considering genetics and sex

  This study is testing how well healthy adults convert an omega-3 supplement into another important fatty acid, while looking at how genetics and sex might affect this process.

  Recruiting Phase 4 University of Toronto · Toronto, Ontario · NCT06975241

• Digital heart-health app and lifestyle program for adults with heart disease or high-risk diabetes

  This program will test whether adding a digital heart-health app and lifestyle support to usual care helps adults on statins with established heart disease or high-risk type 2 diabetes lower their cardiovascular risk.

  Recruiting University of Toronto · Toronto, Ontario · NCT06919302

• Substituting high- with low-ultra-processed soy protein foods within a guideline-based diet for cardiometabolic health

  This study tests whether a 12-week digital diet program with extra fruits and vegetables, combined with either low- or high-ultra-processed soy protein foods, can lower systolic blood pressure in adults with hypertension and obesity, about half of whom have type 2 diabetes.

  Recruiting University of Toronto · Toronto, Ontario · NCT06907862

• Dairy intake and metabolic health in teens and older adults

  This project will test whether eating three servings of dairy each day helps overweight or obese teens (15–18) and older adults (60–80) improve weight, body composition, and metabolic health over six months.

  Recruiting University of Toronto · Toronto, Ontario and 1 other locations · NCT06879652

• Comparing dairy and plant-based foods in adolescents and older adults

  This study tests whether dairy foods or plant-based alternatives are better for controlling blood sugar and providing nutrients in healthy teens and older adults.

  Recruiting University of Toronto · Toronto, Ontario · NCT06874400

• Targeting HIV-infected cells to reduce viral reservoirs

  This study is testing a new way to help people with HIV by using a medication to target and kill the cells that keep the virus alive, aiming to lower the amount of virus in their bodies.

  Recruiting at 2 sites University of Toronto · Toronto, Ontario and 1 other locations · NCT06823596

• Short-term effects of aromatase inhibitor endocrine therapy on heart and brain health in breast cancer

  This project will test whether the first six months of aromatase inhibitor therapy change early heart, metabolic, and brain health measures in postmenopausal women with hormone-receptor–positive, HER2-negative breast cancer compared with age- and BMI-matched controls.

  Recruiting University of Toronto · Toronto, Ontario · NCT06781762

• Effects of Aromatase Inhibitors on Heart and Brain Health in Breast Cancer Survivors

  This study looks at how taking aromatase inhibitors affects heart and brain health over time in post-menopausal women who have survived hormone receptor-positive breast cancer.

  Recruiting University of Toronto · Toronto, Ontario · NCT06776458

• Peer health coaching with a web-based self-management program for people newly discharged after spinal cord injury

  This study will test whether a web-based self-management program with trained peer health coaches helps people within three years of a spinal cord injury manage their health after leaving inpatient rehabilitation.

  Recruiting at 2 sites University of Toronto · Milford, Connecticut and 1 other locations · NCT06677905

• Short post-meal activity and spread-out exercise for breast cancer survivors

  We will test whether short bouts of activity after meals or spreading activity through the day better lower blood sugar than no activity or a standard 30‑minute workout in sedentary, postmenopausal breast cancer survivors on aromatase inhibitors and similar women without cancer.

  Recruiting University of Toronto · Toronto, Ontario · NCT06633380

• Virtual exercise program for cancer survivors

  This study is testing whether a 6-month virtual exercise program can help cancer survivors be more active and improve their quality of life.

  Recruiting University of Toronto · Toronto, Ontario · NCT06624930

• Hand and finger motor recovery using piano-based training after stroke

  This program will try two types of piano-based hand training to see which helps people who had a stroke 6 months to 2 years ago improve finger movements.

  Recruiting at 5 sites University of Toronto · Toronto, Ontario and 4 other locations · NCT06604143

• Online health assessment for older adults undergoing surgery

  This study is testing an online health questionnaire for older adults having surgery to see if it helps doctors make better treatment decisions and reduce complications after surgery.

  Recruiting University of Toronto · Toronto, Ontario · NCT06464471

• Exercise and diet to lower heart and metabolic risk in breast cancer survivors

  This project will test whether a 6-month program of Health Canada–based exercise, with or without a healthy-eating counseling program, helps reduce cardiometabolic risk and improve body composition in postmenopausal women who survived early-stage breast cancer and have overweight.

  Recruiting University of Toronto · Toronto, Ontario · NCT06454864

• Intervention for reducing cardiometabolic risk in women through exercise and diet

  This study is testing whether exercise alone, or exercise combined with diet advice, can help pre and postmenopausal women lower their risk of heart and metabolic issues.

  Recruiting University of Toronto · Toronto, Ontario · NCT06345937

• Bilateral thalamic stimulation for essential tremor treatment

  This study is testing a new brain stimulation treatment for people with essential tremor to see if it can safely improve their symptoms.

  Recruiting University of Toronto · Toronto, Ontario · NCT06325852

• Understanding late talking in children using brain imaging and behavior assessments

  This study is trying to understand why some toddlers talk later than others by looking at their brains and behaviors to help create better support for them.

  Recruiting at 2 sites University of Toronto · Oshawa, Ontario and 1 other locations · NCT06156865

• Eating window timing to improve blood sugar in adults with obesity and type 2 diabetes or at risk

  This study tests whether eating only during one of three nine-hour daily windows can improve blood sugar control in adults with obesity who have or are at risk for type 2 diabetes.

  Recruiting University of Toronto · Toronto, Ontario · NCT06118931

• Examining the effects of combined therapy for schizophrenia

  This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.

  Recruiting at 2 sites University of Toronto · Scarborough Village, Ontario and 1 other locations · NCT05731414

• Cardiac rehabilitation program for women with breast cancer

  This study is testing a 16-week heart health program for women with early-stage breast cancer to see if it helps improve their overall health and well-being.

  Recruiting University of Toronto · Toronto, Ontario · NCT05522959

• Reducing sedentary behavior in prostate cancer survivors

  This study is testing if a special program with support and a FitBit can help prostate cancer survivors move more and sit less over 12 weeks.

  Recruiting University of Toronto · Toronto, Ontario · NCT05214937

• Impact of exercise on brain function in breast cancer patients undergoing chemotherapy

  This study is trying to see if being physically fit helps breast cancer patients think better during and after chemotherapy.

  Recruiting University of Toronto · Toronto, Ontario · NCT04616300

• Biofeedback training for children with idiopathic infantile nystagmus

  This study is testing if biofeedback training can help children with idiopathic infantile nystagmus improve their vision and control their eye movements better.

  Recruiting University of Toronto · Toronto, Ontario · NCT04142307

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Neuroimaging changes with treatment in developmental language disorder (DLD)

  A study using brain imaging in people with developmental language disorder to see how treatment-related changes relate to grammar learning.

  NIH research University of Toronto · Toronto, Canada · NIH-11523800

• Understanding how speech develops in kids who use two dialects or languages

  We’re studying how young children who speak two dialects or languages produce speech sounds, to help clinicians tell apart typical differences from speech delays.

  NIH research University of Toronto · Toronto, Canada · NIH-11402806

• Systematic study of a leading human fungal pathogen and its virulence

  Scientists are studying how Candida albicans causes disease and how it responds to drugs, with the goal of finding new ways to treat dangerous infections.

  NIH research University of Toronto · Toronto, Canada · NIH-11394345

• Targeting Hsp90 in cryptococcal fungal disease

  A patient-centered look at a study that aims to weaken a fungal pathogen (Cryptococcus) by disabling a protein (Hsp90) to make antifungal drugs work better.

  NIH research University of Toronto · Toronto, Canada · NIH-11369645

• Non-viral gene editing to fix cystic fibrosis stop mutations

  This project tests inhaled, non-viral gene editing to correct premature 'stop' mutations in the CFTR gene for people with cystic fibrosis caused by nonsense mutations.

  NIH research University of Toronto · Toronto, Canada · NIH-11320879

• Ferrochelatase: a new target to block abnormal eye blood vessel growth

  A scientist is studying a gene called FECH to understand how to stop unwanted blood vessel growth in diseases like age-related macular degeneration and diabetic retinopathy.

  NIH research University of Toronto · Toronto, Canada · NIH-11307570

• Stopping dangerous yeast infections by blocking a fungal enzyme called Yck2

  This project is developing drugs that block a fungal enzyme (Yck2) to kill drug-resistant Candida infections that often affect people with weakened immune systems.

  NIH research University of Toronto · Toronto, Canada · NIH-11306997

• Developing a new method to treat cystic fibrosis caused by specific genetic mutations

  This study is exploring a new way to help people with cystic fibrosis by using special tools to fix genetic mistakes in their cells, and it will test how well this works and how safe it is in mice before considering it for humans.

  NIH research University of Toronto · Toronto, Canada · NIH-11158740

• How Candida albicans changes shape and becomes harmful

  This project looks at how the common fungus Candida albicans changes and becomes harmful so scientists can find new targets for safer antifungal treatments for people with serious fungal infections.

  NIH research University of Toronto · Toronto, Canada · NIH-11145747

• New Ways to Fight Cryptococcal Fungal Infections

  This research looks for new ways to treat serious fungal infections, like cryptococcal meningitis, by focusing on a specific protein in the fungus.

  NIH research University of Toronto · Toronto, Canada · NIH-11127610

• Targeting a specific kinase to fight fungal infections

  This study is looking at a protein called Yck2 to see how it affects the growth of tough fungal infections like Candida albicans and Candida auris, especially in people with weakened immune systems, and it hopes to find new medicines that can help fight these infections better.

  NIH research University of Toronto · Toronto, Canada · NIH-11049045

• Examining how immigrant integration affects health over time

  This study looks at how the health of older immigrants, especially those from diverse backgrounds, changes as they settle into their new communities over time, focusing on what helps or hinders their physical and mental well-being as they age.

  NIH research University of Toronto · Toronto, Canada · NIH-10979699

• Targeting a protein in fungi to improve antifungal treatments

  This study is looking at a protein called Hsp90 in the fungus that causes serious infections like cryptococcal meningitis, with the goal of creating new antifungal medicines that work better and have fewer side effects for patients.

  NIH research University of Toronto · Toronto, Canada · NIH-10884889

• Understanding brain changes in children with developmental language disorder after treatment

  This study is looking at how different treatments can change the way the brains of preschool kids with developmental language disorder work and connect, to help us understand how they learn grammar and improve their language skills.

  NIH research University of Toronto · Toronto, Canada · NIH-10870000

Quick answers

How many clinical trials run by University of Toronto are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in Canada (31 trials), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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