Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Cardiac rehabilitation program for women with breast cancer

Official title: A Single Arm Intervention Study to Assess the Role of Structured Cardio-Oncology Rehabilitation Exercise to Improve Cardiovascular Health in Early Stage Breast Cancer Survivors (CORE Study)

Run by University of Toronto · NCT05522959 · Data updated 2026-11-12

This study is testing a 16-week heart health program for women with early-stage breast cancer to see if it helps improve their overall health and well-being.

More Breast Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment100 (estimated)
SponsorUniversity of Toronto
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Toronto, Ontario)
StatusRecruiting
StartedMarch 14, 2022
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedOctober 1, 2025
Trial IDNCT05522959 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women with early-stage breast cancer who are currently receiving or have completed adjuvant therapy.

Probably not a fit

Patients with metastatic breast cancer or those unable to complete a cardiopulmonary exercise test may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study invites women with early-stage breast cancer to participate in a 16-week multimodal cardiac rehabilitation program at the Toronto Rehabilitation Institute. Participants will undergo assessments before and after the program to evaluate improvements in cardiometabolic health, including changes in VO₂peak measured by Cardiopulmonary Exercise Test (CPET). The study will also examine traditional cardiac risk factors, lifestyle behaviors, exercise adherence, health-related quality of life, and fatigue levels.

Why it matters

Potential benefit: If successful, this program could significantly improve the cardiovascular health and overall quality of life for women recovering from breast cancer.

How similar studies have gone: Other studies have shown positive outcomes with similar cardiac rehabilitation approaches in cancer patients, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* History of early-stage breast cancer (I-III)
* Currently receiving or have completed adjuvant therapy (i.e. chemotherapy, surgery, radiation, targeted therapies)
* Able to communicate in English

Exclusion Criteria:

* Pregnancy
* Metastatic disease (Stage IV)
* Unable or unwilling to complete cardiopulmonary exercise test

Where it's running

  • Toronto Rehabilitation Institute
    Toronto, Ontario, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.